BACKGROUND Carbohydrate-deficient transferrin (CDT) is a well-recognized highly specific marker of chronic alcohol abuse. The association of CDT with alcohol-related traffic accidents was evaluated to objectively validate the use of this marker for certifying the physical fitness for driving license regranting after its confiscation for drunk driving. METHODS The study was carried out on 468 ...

In this paper we consider a block-structured convex optimization model, where in the objec-tive the block-variables are nonseparable and they are further linearly coupled in the constraint.For the 2-block case, we propose a number of first-order algorithms to solve this model. First,the alternating direction method of multipliers (ADMM) is extended, assuming that it is easyto op...

This paper describes and demonstrates a new and highly innovative technique that identifies an approximation of the entire bounding surface of the feasible objective region directly, including deep concavities, disconnected regions and the edges of interior holes in the feasible areas. The Pareto front is a subset of the surface of the objective boundary and can be extracted easily. Importantly...

This paper introduces a context-oriented component-based application MDA (COCA-MDA) that modularizes the application’s context-dependent behaviour into context-oriented components. The components separate the application’s functional concerns from the extra-functional concerns. The application is organized into two casually connected layers: the base layer, which provides the application’s core...