The low extracellular pH of inflamed or ischemic tissues enhances painful sensations by sensitizing and activating the vanilloid receptor 1 (TRPV1). We report here that activation of TRPV1 results in a marked intracellular acidification in nociceptive dorsal root ganglion neurons and in a heterologous expression system. A characterization of the underlying mechanisms revealed a Ca(2+)-dependent...

Wettability has a strong influence on multi-phase flow behavior through reservoir rock. Reservoir rocks tend to have spatially varying wettability. Prior contact with oil, are almost always naturally water-wet. As oil invades the pore-space over geologic time, initial water-wet state may be altered in certain locations due adhesion of substances within phase grains. Mechanisms wettability alter...

abstract at present study constant rate of strain (crs) consolidation under non-darcy condition was investigated. in this study a governing conditions of drainage pore water were investigated using proposed equation. the crs experiments under different rates of strain were conducted on different soil samples. results these experiments and there comparison with proposed equation showed that flow...

Pore network models are used to relate fundamental pore structure parameters (pore body and pore throat size distributions) to the distribution of water at the pore level and the decay of proton magnetization under conditions of primary drainage in water-wet rocks. The simulations reveal conditions under which diffusive coupling between pores has a significant effect on the decay spectra and pr...

The May 19, 2006 issue of Science included a paper by Holt et al. on "Fast Mass Transport Through Sub-2-Nanometer Carbon Nanotubes". The paper was also featured on the cover, showing methane molecules translating inside a carbon nanotube (CNT). The authors explained how they prepared 2-6-mum thin membranes consisting of double-walled carbon nanotubes (DWNTs) all aligned perpendicular to the app...

The venom of the common Indian krait (Bungarus caeruleus) contains about a dozen isoforms of phospholipase A2 (PLA2), which exist in different oligomeric forms as well as in complexes with low-molecular-weight ligands. The basic objective of multimerization and complexation is either to inactivate PLA2 in the venom for long-term storage, to generate a new PLA2 function or to make a more lethal ...

The coupled mechanics of fluid-filled granular media controls the physics of many Earth systems such as saturated soils, fault gouge, and landslide shear zones. It is well established that when the pore fluid pressure rises, the shear resistance of fluid-filled granular systems decreases, and as a result catastrophic events such as soil liquefaction, earthquakes, and accelerating landslides may...