نتایج جستجو برای: fih
تعداد نتایج: 235 فیلتر نتایج به سال:
Ah.WoCl-A m u l t i o d e fih+matched arrayed waveguide grating-based demultiplexer has befn demonstrated. In thb design. multimode waveguides have been used 85 m y clements. The device, which can he used in short-dbtance communications, has been realized using low-cos1 polymer planar waveguide technology. Three wavclenglh ehanncls were SUCC~S. fully separsled. The average fiber-to-fiber inserl...
Hypoxia-inducible factor (HIF)-1 plays a key role in tumor promotion by inducing f60 genes required for tumor adaptation to hypoxia; thus, it is viewed as a target for cancer therapy. For this reason, YC-1, which downregulates HIF-1A and HIF-2A at the post-translational level, is being developed as a novel anticancer drug. We here found that YC-1 acts in a novel manner to inhibit HIF-1. In the ...
1 Research Institute Havelhöhe (FIH), Havelhöhe Hospital, 14089 Berlin, Germany 2Department of Oncology, Havelhöhe Hospital, 14089 Berlin, Germany 3 Institute for Social Medicine, Epidemiology and Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medicine, 14089 Berlin, Germany 4 Institute of Integrative Medicine, University of Witten/Herdecke, 58313 Herdecke,...
The condition f(x + 2h) 2f(x + h) + f(x) = o(l) (as h -* 0) at each x is equivalent to continuity for measurable functions. But there is a discontinuous function satisfying 2f(x + 2h) f(x + h) f(x) = o(l) at each x. The question of which generalized Riemann derivatives of order 0 characterize continuity is studied. In particular, a measurable function satisfying EZI1if(x + fih) _ 0 must be a po...
Hypoxic and oxidant stresses can coexist in biological systems, and oxidant stress has been proposed to activate hypoxia pathways through the inactivation of the 'oxygen-sensing' hypoxia-inducible factor (HIF) prolyl and asparaginyl hydroxylases. Here, we show that despite reduced sensitivity to cellular hypoxia, the HIF asparaginyl hydroxylase--known as FIH, factor inhibiting HIF--is strikingl...
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