12,13-Difluorofarnesyl diphosphate, prepared using Suzuki-Miyaura chemistry, is a potent inhibitor of aristolochene synthase (AS), indicating that the initial cyclisation during AS catalysis generates germacryl cation in a concerted reaction.

Many individuals with substance use disorders are resistant to entering formal treatment, despite the negative consequences that plague their own lives and the lives of concerned significant others (CSOs). Community Reinforcement and Family Training (CRAFT) has been developed as an effective strategy for helping family members who are concerned about the alcohol/drug use of a loved one who refu...

APETx2 is a peptide isolated from the sea anemone Anthopleura elegantissima. It is the most potent and selective inhibitor of acid-sensing ion channel 3 (ASIC3) and it is currently in preclinical studies as a novel analgesic for the treatment of chronic inflammatory pain. As a peptide it faces many challenges in the drug development process, including the potential lack of stability often assoc...

A one-pot cyclisation/oxidation process results in a new constrained-cavity Schiff-base dipyrrin macrocycle and allows access to Li, Fe, Zn complexes of this unique chromophore.

The first synthesis of a 6,6'-biindole and 6,6'-biisatin scaffold is reported with the penultimate step being the formation of the di-heterocyclic ring by Pd(II)-catalysed intramolecular C-H functionalisation and Sandmeyer cyclisation, respectively.

Dihydropyrans have been prepared by the cyclisation of easily accessible propargyl vinyl ethers with (TFP)AuCl/AgBF(4) as a catalyst in high yields. These compounds undergo acid-catalysed rearrangement into cyclopentenone derivatives.

A straightforward and efficient synthesis of sesterstatins 4 and 5 is reported, in which the reductive Heck cyclisation was employed as the key step for constructing the D ring.

The functionalisation of decalin by means of an "aliphatic Friedel-Crafts" reaction was reported over fifty years ago by Baddeley et al. This protocol is of current relevance in the context of C-H activation and here we demonstrate its applicability to a range of other saturated hydrocarbons. Structural elucidation of the products is described and a mechanistic rationale for their formation is ...

Recently, digital archives for cultural heritage or arts and crafts has received attention from possibility that people can appreciate or experience the archaeological objects, the past space or arts and crafts through the computer at any time and without going to the museum or the spot. In particular, 3D reconstruction and visualization of the lost objects or past word using antique maps or pi...

TBRT allows the control of cyclisation within branched polymer architectures by simply changing dilution. Increased leads to changes in physical properties, therefore, tunig behaviour is available without starting materials.