The fibrinolytic system is responsible for physiological lysis of hemostatic plugs once vascular integrity has been restored after injury. The formation and regulation of plasmin proceeds in a very similar way to the formation and regulation of thrombin in the coagulation cascade.1 Complex regulatory pathways, which include cell surfaces, the fibrin surface, the structure of the fibrin clot, an...

Poor knowledge of stroke risk factors and failure to recognize and act on acute symptoms hinders efforts to prevent stroke and improve clinical outcomes. Levels of stroke knowledge are poorly established within Ireland. This study was conducted to establish levels of knowledge among men and women aged >40 years in an Irish community, and also to determine the impact of a single education sessio...

Fibrinolytic therapy of venous thromboembolism (VTE) is increasingly utilized, yet limited knowledge is available regarding in vivo mechanisms that govern fibrinolytic efficacy. In particular, it is unknown how age-dependent thrombus organization limits direct blood contact with fibrin, the target of blood-based fibrinolytic agents. Utilizing high-resolution in vivo optical molecular imaging wi...

The use of fibrinolytic agents in the early treatment of ST-segment elevation myocardial infarction (STEMI) is known to significantly reduce mortality. Accelerated (“frontloaded”) alteplase is being challenged as the standard of care for pharmacological reperfusion. Alteplase, reteplase, and streptokinase have several limitations. The search for newer agents has focused on developing a fibrinol...

OBJECTIVES This study was designed to analyze the results of fibrinolytic treatment (FT) in a large single-center group of patients with prosthetic heart valve thrombosis (PHVT). BACKGROUND Fibrinolytic treatment of PHVT represents an alternative to surgery, but is still controversial because of the risk of embolism. METHODS A total of 110 consecutive patients presenting with 127 instances ...

Fibrinolytic proteases operate directly on fibrin clot and are able to maintain blood flow. Fungi show up as viable sources for obtaining this enzyme. The purpose of systematic review is unveil all the information concerning production, purification characterization fibrinolytic by fungi. search was conducted in ScienceDirect, PubMed Scopus databases, using keywords “(Fibrinolytic enzyme) OR (F...

The process of fibrin clot formation is a series of complex and well-regulated reactions involving blood vessels, platelets, procoagulant plasma proteins, natural inhibitors, and fibrinolytic enzymes. Vasculitis can be caused by a variety of different agents as bacteria, viruses, protozoal, rickettsial organisms, toxic, drugs, medications, and neoplasms. The most common cause of vasculitis is t...