The objective of this study was to evaluate the impact of obesity and firefighting activities on coagulation and fibrinolytic activity in relatively young, apparently healthy firefighters. Firefighters performed simulated firefighting activities for 18 minutes in a live-fire training structure. Blood samples were obtained at baseline, before firefighting, and within a few minutes of completing ...

The effects of acute fat feeding on fibrinolytic activity, platelet aggregation, and Stypven time in 10 Africans and 10 Asians are presented and compared with the results previously obtained in 10 Europeans. These indicated that the inhibition of fibrinolytic activity seen in Europeans does not occur in either Africans or Asians although the Stypven time was shortened in all three groups. Plate...

Fibrinolytic activity, using euglobulin lysis time (ELT), was assessed in 46 Nigerians with type 2 diabetes mellitus to study the effect of the disease on fibrinolytic component of haemostasis. There were 20 females and 26 males. Fifty age matched non-diabetics and apparently healthy Nigerians were similarly studied as controls; there were 24 females and 26 males. In the patients, the mean (SD)...

This investigation was undertaken in normal subjects to define the relationship between the intensity of exercise and magnitude of fibrinolytic response and to examine the effect of diurnal variations on the exercise response. Fibrinolytic activity was measured on fibrin plates and expressed as mm2. Diurnal variations occurred with lowest activity at 8:00 AM (mean, 66 mm), and peak activity bet...

Nattokinase, Streptokinase and Urokinase are novel fibrinolytic enzymes which are isolated from Bacillus subtilis, β-haemolytic Streptococci and urine sample. The fibrinolytic enzyme Nattokinase, Streptokinase and Urokinase was purified from supernatant of Bacillus subtilis, β-haemolytic Streptococci and recombinant E.coli containing short fragment genomic DNA of Pseudomonas sp. Culture broth a...

The distribution of plasminogen activator in fresh human prostatic tissue has been studied, using a histological technique. The vascular endothelium consistently showed fibrinolytic activity while inconstant and lesser activity arose from the epithelial cells of glands and ducts. Increased epithelial activity was often accompanied by evidence of trauma. Activity of the secretions was insignific...

Background. Numerous investigators have observed that pulmonary emboli are rapidly lysed in a canine model system. This study was undertaken to delineate the unique mechanism that accounts for the rapid dissolution of pulmonary emboli in mongrel dogs. Methods and Results. Canine plasminogen activator (PA) activity (2.6± 1.1 IU/mL acidified platelet-poor plasma [PPP], <0.3 IU/mL acidified whole ...

The increasing recognition of non-arteriosclerotic endomyocardial fibrosis as a significant cause of congestive cardiac failure in adults outside Africa as well as in Africa is noted. Five new cases occurring in Great Britain (one in an African) are added to the mounting literature on the subject. The main clinical and pathological features are summarized, and the suggestion is made that early ...

The spontaneous fibrinolytic activity of blood is due to a labile activator which appears to be stabilized by adsorption to fibrin (Fearnley and Tweed, 1953; Fearnley, 1953; Flute, 1960). At present activator activity can be measured only indirectly through its conversion of plasminogen to plasmin which in turn causes fibrinolysis. Whatever method is used it is essential to cool the blood sampl...

In order to study the fibrinolytic activity of vein walls in smokers and nonsmokers, 71 randomly selected heavy smokers, i.e., smoking more than 15 g tobacco per day, and 41 nonsmokers from the population group "Men born in 1914 residing in Malmo" were invited to undergo a health examination. When examined after 12 hours' abstention from tobacco, the smokers were found to have the same fibrinol...