Antiphospholipid syndrome (APS) is defined as the occurrence of thrombosis, recurrent miscarriage, or both in association with laboratory evidence of persistent antiphospholipid antibodies. Owing to protean manifestations and laboratory studies, the diagnosis may be difficult. Because the other signs and symptoms of thrombosis are predominant, prolonged fever is not usually the main clinical fi...

Background Fever of unknown origin (FUO) and unexplained signs of inflammation are challenging medical problems and predominantly caused by infections, malignancies and noninfectious inflammatory diseases. The aim of this study was to assess the diagnostic value of fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDGPET) and of its combination with computer tomography technology...

Knowledge about the etiology of fever of unknown origin (FUO) has been changed under the influence of new advances in diagnostic techniques in both adulthood and childhood. Seventy-seven patients with the diagnosis of FUO were evaluated retrospectively. Forty-six (60%) of the patients were male and 31 (40%) were female, with ages ranging from 4 months to 16 years (mean: 4.5 years). Physical fin...

Twenty patients affected by fever of unknown origin (FUO), due to a likely infection of the muscular or skeletal tissues, were studied by a Total Body scan with a monoclonal antibody fragment (Leukoscan) labelled with Tc-99m. The diagnostic procedure helped reach a final diagnosis in 8 out of the 20 patients because it identified the focus of the infection of the muscles or bones in joint proxi...

OBJECTIVES Fever of unknown origin (FUO) remains a challenge in clinical practice. Fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is helpful in diagnosing the etiology of FUO. This paper aims to develop a completely automatic classification method based on PET/CT data for the computer-assisted diagnosis of FUO. METHODS We retrospectively analyze...

The aim of this study was to determine the causes of fever of unknown origin (FUO) at a tertiary care teaching hospital in Pakistan. We conducted this cross sectional descriptive study at the Department of Medicine, Civil Hospital Karachi, from January 2006 to December 2011. We reviewed the medical records of all patients aged > 12 years with a primary diagnosis of FUO. We excluded those who di...

Adult-Onset Still's Disease (AOSD) is a rare systemic inflammatory disease of unknown etiology and pathogenesis. AOSD presents in 5% to 10% of patients as Fever of Unknown Origin (FUO) accompanied by systemic manifestations. We reported a compelling case of a 39-year-old African male presenting one-month FUO along with skin rash, sore throat, and arthralgia. After an extensive workup, potential...

BACKGROUND/AIM Fewer of unknown origin (FUO) remains amongst the most difficult diagnostic dilemmas in contemporary medicine. The aim of this study was to determine the causes of FU and to identify the methods of diagnosis in patients with FUO in a tertiary care setting in the Republic of Macedonia. METHODS Retrospectively histories of 123 immunocompetent patients older than 14 years with cla...