نتایج جستجو برای: fetal defects
تعداد نتایج: 218360 فیلتر نتایج به سال:
BACKGROUND A successful outcome of pregnancy requires an efficient uteroplacental vascular system. Since this system may be compromised by disorders of haemostasis associated with a prothrombotic state, we postulated that maternal thrombophilia might be a risk factor for fetal loss. We studied the relation between heritable thrombophilic defects and fetal loss in a cohort of women with factor V...
OBJECTIVE To determine the likelihood ratio for trisomy 21 in fetuses with tricuspid regurgitation at the 11 to 13 + 6-week scan. METHODS Fetal echocardiography was carried out by specialist pediatric cardiologists in 742 singleton pregnancies at 11 to 13 + 6 weeks' gestation and pulsed wave Doppler was used to ascertain the presence or absence of tricuspid regurgitation. To avoid confusion w...
BACKGROUND Mice are well suited for modeling human congenital heart disease (CHD), given their 4-chamber cardiac anatomy. However, mice with CHD invariably die prenatally/neonatally, causing CHD phenotypes to be missed. Therefore, we investigated the efficacy of noninvasive microcomputed tomography (micro-CT) to screen for CHD in stillborn/fetal mice. These studies were performed using chemical...
arsenic is an important environmental toxicant which is usually found in drinking water in inorganic form. the hypothesis tested in this investigation is; arsenic exposure causes neural tube defects (ntds) andthese defects of the central nervous system are more likely related to folate deficiency during fetal life. in this study, sodium arsenate was administered via intraperitoneal route at a r...
Maternal undernutrition during pregnancy and placental insufficiency are characterized by impaired development of fetal pancreatic β-cells. Prolonged reduced glucose supply to the fetus is a feature of both. It is unknown if reduced glucose supply, independent of other complications of maternal undernutrition and placental insufficiency, would cause similar β-cell defects. Therefore, we measure...
Purpose: Maternal type-1 diabetes during pregnancy causes an increased rate of malformation in fetuses.Many studies have demonstrated that an increase in the plasma level of free 02 radicals may increase the rate of abnormalities in the offspring of diabetic mothers. Because vitamin E is an active antioxidant, it may be able to decrease free 02 radicals and protect fetuses against congenital ma...
Maternal consumption of alcohol (ethanol) can result in a range of alcohol-induced developmental defects. In humans [5], those collective birth defects [6] are called Fetal Alcohol Spectrum Disorders, with the most severe manifestation being Fetal Alcohol Syndrome [7] (FAS). FAS is defined by preand post-natal growth retardation [8], minor facial abnormalities, and deficiencies in the central n...
Maternal consumption of alcohol (ethanol) can result in a range of alcohol-induced developmental defects. In humans [5], those collective birth defects [6] are called Fetal Alcohol Spectrum Disorders, with the most severe manifestation being Fetal Alcohol Syndrome [7] (FAS). FAS is defined by preand post-natal growth retardation [8], minor facial abnormalities, and deficiencies in the central n...
A single-blind study involving amniotic-fluid samples from 214 pregnancies of known outcome confirms that an electrophoretically distinct isoenzyme of acetylcholinesterase is associated with fetal open neural tube defects. Furthermore, only one of 13 amniotic-fluid samples with false-positive results for alpha-fetoprotein showed the characteristic isoenzyme, indicating that qualitative acetylch...
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