Human and animal studies on sleep-disordered breathing and respiratory regulation show that the effects of sex hormones are heterogeneous. Because neonatal stress results in sex-specific disruption of the respiratory control in adult rats, we postulate that it might affect respiratory control modulation induced by ovarian steroids in female rats. The hypoxic ventilatory response (HVR) of adult ...

Animals like plants are also medicinal agents for the prevention and cure of different health problems all over world practically in about human cultures. The concept zootherapy is very old has strong evidence use animal resources. Different animals their body parts preparations used folk medicines. Zootherapy reveals that medical practitioners have always considered as a source surprising nume...

Male and female ACI rats were inoculated with the syngeneic H-4-II-E hepatoma, and the natural history of the tumor, histopathology, and lymphocyte migration were studied. The tumor formed a.s.c. mass in all 16 males and in 22 of the 26 females given injections. In the males, tumors progressed, and all animals died with the mean survival time of 54 days. Complete tumor regression was observed i...

Administration of nicotine leads to incentive and behavioral tolerance in human and animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effects of ascorbic acid administration on the expression and development of nicotine-induced behavioral tolerance in female Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.5 m...

Administration of nicotine leads to incentive and behavioral tolerance in human and animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effects of ascorbic acid administration on the expression and development of nicotine-induced behavioral tolerance in female Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.5 m...

There is evidence from clinical studies and animal experiments that aspirin has a greater antithrombotic activity in males compared to females. We investigated platelet function in vitro and in vivo in rabbits before and after the administration of a dose of aspirin (5 mg/kg) which inhibited collagen stimulated thromboxane B2 generation. Infusion of collagen into untreated animals resulted in a...

Toxic effects of trace elements upon the hypothalamic- pituitarytesticular axis and sex hormones have been reported in recent years. It is generally considered that CdCl2 poisoning causes histopathological changes in the testicles of male rats. Little attention had been drawn to the possible toxic effects of CdCl2 on the ovary and female sex hormones. The purpose of the present study was t...

A bioassay for the possible carcinogenicity of trimethylthiourea was conducted using Fischer 344 rats and B6C3F1 mice. A mixture containing 80 percent trimethylthiourea and 15 percent dimethylthiourea was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. Twenty animals of each sex and species were placed on test as controls. T...

Jel ínek F. : Spontaneous Tumours in Guinea Pigs. Acta Vet. Brno 2003, 72: 221-228. The aim of the study is to describe spontaneous tumours in guinea pigs. Twenty neoplasias from 19 guinea pigs were examined histologically. In 15 cases biopsy samples were examined, samples from four animals were collected during autopsy. Except for one, all animals were kept as pets. Skin tumours were diagnosed...