The objective of present work was development of felodipine nano emulsion formulations using sesame oil as sole lipid phase by high pressure homogenization technique. A combination of non-ionic surfactants was used based on HLB (Hydrophilic lipophilic balance) values. The resultant nano emulsions were characterized for particle size, zeta potential. The particle size for the optimized nano emul...

Purpose: With the introduction of combinatorial chemistry and high throughput screening, the properties of new chemical entities shifted towards higher molecular weight and increasing lipophilicity that results in decreasing aqueous solubility. It is not surprising that many drug candidates have poor water solubility since the initial selection of drug candidates are based on activity alone. Ot...

Studies in patients with congestive heart failure (CHF) have demonstrated an abnormal /3-adrenergic reflex vasodilation during orthostatic tilt. Baroreflex modulation of vascular resistance in patients with CHF was investigated during therapy with a vasoselective calcium antagonist, felodipinre. Eight patients on conventional therapy for severe CHF were studied after a 3 week course of addition...

Herein, new extended-release tablets containing felodipine were developed. For the orally administered formulations, optimization of preformulation and formulation parameters was performed to assess performance dosage form. Initially, morphological physical characterization two forms (microcrystalline macrocrystalline) using Fourier transform infrared spectroscopy, differential scanning calorim...