Prostate cancer as well as other solid cancers are embedded in and supported by the surrounding tumour microenvironment, which usually consists of fibroblasts, smooth muscle cells, endothelial cells and immune cells. In the prostate, fibroblasts and smooth muscle cells represent the bulk of the stroma in both normal and malignant conditions. In carcinomas, there are also pro-tumourigenic cancer...

The detoxifying enzymes can influence the efficacy and toxicity of chemotherapy and also the risk for the devlopment of leukemia. Acute lymphoblastic leukemia, the most common pediatric cancer, is a complex disease determined by a combination of genetic and environmental factors.Important environmental carcinogens are detoxified through the glutathione S-transferases(GSTs) system which includes...

GSAO (4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid) is a novel organoarsenical compound presently completing phase I trials in cancer patients who are refractory to treatment. GSAO targets the mitochondria of proliferating endothelial cells by binding to calcium-replete adenine nucleotide translocase on the inner mitochondrial membrane. Consequently, small solutes equilibrate across th...