SIR, – Feline infectious peritonitis (FIP) is caused by feline coronavirus (FCoV). It is a well known and widely distributed coronavirus-induced systemic disease in cats and non-domestic felids (O’Reilly and others 1979, Kennedy and others 2002). The disease is characterised by fibrinous to granulomatous serositis with protein-rich effusions in body cavities and granulomatous inflammatory lesio...

Feline Infectious Peritonitis (FIP) is a fatal disease caused by feline coronaviruses. The causative agent Virus, mutation of Enteric Coronavirus. Corona Virus very common in the cat population. In infected cats, development FIP depends on cat's immune response. more young and old cats because animals have weaker system. acute phase response complex systemic reaction that occurs as to or chroni...

The gene encoding the spike glycoprotein of the human coronavirus HCV 229E has been cloned and sequenced. This analysis predicts an S polypeptide of 1173 amino acids with an Mr of 128,600. The polypeptide has 30 potential N-glycosylation sites. A number of structural features typical of coronavirus S proteins can be recognized, including a signal sequence, a membrane anchor, heptad repeat struc...

BACKGROUND Feline infectious peritonitis (FIP) is a feline coronavirus-induced fatal disease in domestic and wild cats. Cellular immunity is considered to play an important role in the prevention of FIP. Thus, induction of the cellular immune response is essential in vaccines against FIP virus (FIPV) infection. METHODS We immunized cats with peptides containing T-helper (Th)1 epitopes derived...

The peplomer gene of feline infectious peritonitis virus (FIPV) strain 79-1146 was isolated from a genomic cDNA library by differential hybridization with RNA 2 and 3 as probes. From the nucleotide sequence a primary translation product of 1452 residues (Mr 160,472) was predicted, containing an N-terminal signal sequence, a C-terminal transmembrane segment and 35 potential N-linked glycosylatio...

Feline coronaviruses (FCoV) vary widely in virulence causing a spectrum of clinical manifestations reaching from subclinical course to fatal feline infectious peritonitis (FIP). Independent of virulence variations they are separated into two different types, type I, the original FCoV, and type II, which is closely related to canine coronavirus (CCV). The prevalence of FCoV types in Austrian cat...

Feline infectious peritonitis virus (FIPV), a coronavirus that causes a lethal chronic disease in cats, enters feline monocytes via endocytosis. In this study, the pathway of internalization is characterized by evaluating the effect of chemical inhibitors and/or expression of dominant-negative (DN) proteins on the percentage of internalized virions per cell and infection. Further, co-localizati...