This paper extends the theory of false discovery rates (FDR) pioneered by Benjamini and Hochberg (1995). We develop a framework in which the False Discovery Proportion (FDP) – the number of false rejections divided by the number of rejections – is treated as a stochastic process. After obtaining the limiting distribution of the process, we demonstrate the validitiy of a class of procedures for ...

Latent trajectory models (LTMs) characterize longitudinal data using a finite mixture of curves. We address uncertainty in the number of latent classes and in the form of the class-specific curves using a semiparametric Bayesian approach. A mixture of functional Dirichlet processes (FDP) is used to characterize the distribution of longitudinal trajectories. The FDP is defined by replacing the a...

Loss of experimental animals due to tendon repair failure results in the need for additional animals to complete the study. We designed a relief proximal to the flexor digitorum profundus (FDP) tendon repair site to serve as a "safety incision" to prevent repair site ruptures and maximize safety incision-to-suture strength. The FDP tendons were dissected in 24 canine forepaws. The 2nd and 5th t...

OBJECTIVE To compare the ability of 24-2 frequency-doubling perimetry (FDP-Matrix) with standard automated perimetry with the Swedish interactive threshold algorithm (SAP-SITA) in detection of visual function abnormalities in patients with glaucomatous-appearing optic discs (GAOD). METHODS This observational case-control study included 80 patients with GAOD and 54 control subjects diagnosed b...

Two D-ketohexose 1,6-diphosphate aldolases are present in Streptococcus cremoris E8 and S. lactis C10. One aldolase, which was induced by growth on either lactose or galactose, was active with both tagatose 1,6-diphosphate (TDP) and fructose 1,6-diphosphate (FDP), having a lower Km and a higher Vmax with TDP as the substrate. This enzyme, named TDP aldolase, had properties typical of a class I ...

The probability of false discovery proportion (FDP) exceeding γ ∈ [0,1), defined as γ-FDP, has received much attention as a measure of false discoveries in multiple testing. Although this measure has received acceptance due to its relevance under dependency, not much progress has been made yet advancing its theory under such dependency in a nonasymptotic setting, which motivates our research in...

BACKGROUND: Preeclampsia is one of the commonest complications of pregnancy. It is associated with a state of hypercoagulability. The present study aimed to estimate the plasma fibrinogen and plasma FDP levels in preeclampsiaas compared to normal pregnancies. METHODS: This is a case-control hospital based study with normal pregnant women (n=36) and women with preeclampsia (n=64) in their third ...

Consider the problem of testing multiple null hypotheses. A classical approach to dealing with the multiplicity problem is to restrict attention to procedures that control the familywise error rate (FWER), the probability of even one false rejection. However, if s is large, control of the FWER is so stringent that the ability of a procedure which controls the FWER to detect false null hypothese...

Rabbit polyclonal antibodies directed against purified Streptococcus mutans L-(+)-lactate dehydrogenase reacted with the purified enzyme, giving a marked deviation of its kinetic parameters. The enzyme affinity for pyruvate or NADH decreased in the presence of antibody, the affinity for fructose 1,6-diphosphate (FDP) appeared to be slightly affected, and the cooperativity of the ligand binding ...

BACKGROUND A specific association between cancer and the hemostatic system has been recognized for decades. Fibrinogen degradation product (FDP) is one of the factors, which opposes coagulation causing fibrinolysis. The mechanism of fibrinolysis can be used by the malignant cells to facilitate invasion into surrounding tissues and metastases to distant organs by breaking the fibrin barrier. The...