BACKGROUND/AIM Switching the patient from one pharmaceutical formulation of the same drug to another, may lead to therapeutic inadequancy in some cases. To minimize the risk, careful pharmacokinetic studies are desired in the pre-registration period and afterwards. METHODS A randomized, crossover design with one-week wash-out period between each dose was applied. Serum samples, obtained befor...

In the case of chronic illnesses, fast-dissolving drug delivery systems were developed as an oral medication administration alternative to traditional dose forms. For masking taste unpleasant drugs and enhancing patient compliance, films are now recommended over tablets capsules. Fast dissolving consist a very thin strip that dissolves in less than one minute when placed on tongue. Customers ha...

Tizanidine HCl is a centrally acting α-2 adrenergic agonist muscle relaxant. It is slightly bitter in taste. In the present study an attempt has been made to prepare bitterless fast dissolving tablet of Tizanidine Hydrochloride using Eudragit E 100 as a taste masking agent. Mass extrusion was the technique used for preparing taste masked granules. The tablet was prepared with three super disint...

Deparment of Pharmaceutics. Dean, Galgotias University,School of Medical and Allied Sciences, Deparment of Pharmaceutics. HOD, Galgotias University,School of Medical and Allied Sciences, Deparment of Pharmaceutics. [email protected] Contact no: 9718369167 ABSTRACT The oral route is more suitable than other route of administration of therapeutic agents due to low cost of therapy and eas...