BACKGROUND The vast majority of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) cases are sporadic and caused by somatic mutations. However, over the last decades several families have been identified with clustering of EAC. Here, we review data from the published literature in order to address the current knowledge on familial EAC. SUMMARY Although familial EAC comprises a relat...

A mail questionnaire was distributed to residents of a retirement community as part of a study of factors associ ated with cancer risk in the elderly. Maternal and paternal age and birth order were not associated with increased risk. With the exception of a positive association between heart disease and prostate cancer, there was no association between a personal or familial history of allergy,...

BACKGROUND A recent recalibration of the ONCOTYROL Prostate Cancer Outcome and Policy (PCOP) Model, assuming that latent prostate cancer (PCa) detectable at autopsy might be detectable by screening as well, resulted in considerable worsening of the benefit-harm balance of screening. In this study, we used the recalibrated model to assess the effects of familial risk, quality of life (QoL) prefe...

BACKGROUND We examined all-cause mortality and long-term thromboembolic risk (ischemic stroke, transient ischemic attack, systemic thromboembolism) in patients with and without familial atrial fibrillation (AF). METHODS AND RESULTS Using Danish nationwide registry data, we identified all patients diagnosed with AF (1995-2012) and divided them into those with familial AF (having a first-degree...

Frenchwomen with HPV-positive carcinoma of the cervix. Int J Cancer 1996;69:159-64. (16) Schneider NR, Chaganti SR, German J, Chaganti RS. Familial predisposition to cancer and age at onset of disease in randomly selected cancer patients. Am J Hum Genet 1983;35:454-67. (17) Weiss KM, Chakraborty R, Smouse PE, Buchanan AV, Strong LC. Familial aggregation of cancer in Laredo, Texas: a generally l...

patients and methods this cross-sectional study was performed on 1202 ms patients in farshchian hospital, hamadan, in 2013. all patients were diagnosed with definite ms. a questionnaire was used to gather information; demographic characteristics, medical history, signs and symptoms at onset, course of disease, relatives with ms, and degree and type of relationship were recorded. conclusions the...