نتایج جستجو برای: factor forkhead box o1 foxo1

تعداد نتایج: 923682  

Journal: :American journal of physiology. Endocrinology and metabolism 2012
Masaki Kobayashi Osamu Kikuchi Tsutomu Sasaki Hye-Jin Kim Hiromi Yokota-Hashimoto Yong-Soo Lee Kosuke Amano Tomoya Kitazumi Vina Yanti Susanti Yukari Ido Kitamura Tadahiro Kitamura

Diabetes is characterized by an absolute or relative deficiency of pancreatic β-cells. New strategies to accelerate β-cell neogenesis or maintain existing β-cells are desired for future therapies against diabetes. We previously reported that forkhead box O1 (FoxO1) inhibits β-cell growth through a Pdx1-mediated mechanism. However, we also reported that FoxO1 protects against β-cell failure via ...

Journal: :The Journal of nutritional biochemistry 2014
Alba Rebollo Núria Roglans Miguel Baena Anna Padrosa Rosa M Sánchez Manuel Merlos Marta Alegret Juan C Laguna

High consumption of fructose-sweetened beverages has been linked to a high prevalence of chronic metabolic diseases. We have previously shown that a short course of fructose supplementation as a liquid solution induces glucose intolerance in female rats. In the present work, we characterized the fructose-driven changes in the liver and the molecular pathways involved. To this end, female rats w...

2014
Christiane Bumke-Vogt Martin A. Osterhoff Andrea Borchert Valentina Guzman-Perez Zeinab Sarem Andreas L. Birkenfeld Volker Bähr Andreas F. H. Pfeiffer

The flavones apigenin (4',5,7,-trihydroxyflavone) and luteolin (3',4',5,7,-tetrahydroxyflavone) are plant secondary metabolites with antioxidant, antiinflammatory, and anticancer activities. We evaluated their impact on cell signaling pathways related to insulin-resistance and type 2 diabetes. Apigenin and luteolin were identified in our U-2 OS (human osteosarcoma) cell screening assay for micr...

2012
Alexandra Dumitriu Jeanne C. Latourelle Tiffany C. Hadzi Nathan Pankratz Dan Garza John P. Miller Jeffery M. Vance Tatiana Foroud Thomas G. Beach Richard H. Myers

Parkinson disease (PD) is a complex neurodegenerative disorder with largely unknown genetic mechanisms. While the degeneration of dopaminergic neurons in PD mainly takes place in the substantia nigra pars compacta (SN) region, other brain areas, including the prefrontal cortex, develop Lewy bodies, the neuropathological hallmark of PD. We generated and analyzed expression data from the prefront...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2012
Lazar A Bojic Cynthia G Sawyez Dawn E Telford Jane Y Edwards Robert A Hegele Murray W Huff

OBJECTIVE Hypertriglyceridemia is an important risk factor for cardiovascular disease. Elevated plasma very low-density lipoprotein (VLDL) puts insulin-resistant patients at risk for atherosclerosis. VLDL readily induces macrophage lipid accumulation and inflammatory responses, for which targeted therapeutic strategies remain elusive. We examined the ability of VLDL to induce macrophage foam ce...

2012
Ziqing Wu Huabin Sun Weixia Zeng Jincan He Xiangming Mao

Forkhead box protein O1 (FOXO1), a key member of the FOXO family of transcription factors, acts as a tumor suppressor and has been associated with various key cellular functions, including cell growth, differentiation, apoptosis and angiogenesis. Therefore, it is puzzling why FOXO protein expression is downregulated in cancer cells. MicroRNAs, non-coding 20~22 nucleotide single-stranded RNAs, r...

Journal: :The Journal of biological chemistry 2016
Meenu Rohini Rajan Elin Nyman Preben Kjølhede Gunnar Cedersund Peter Strålfors

Insulin resistance is a major aspect of type 2 diabetes (T2D), which results from impaired insulin signaling in target cells. Signaling to regulate forkhead box protein O1 (FOXO1) may be the most important mechanism for insulin to control transcription. Despite this, little is known about how insulin regulates FOXO1 and how FOXO1 may contribute to insulin resistance in adipocytes, which are the...

2013
Jian-Mei Li Wei Wang Chen-Yu Fan Ming-Xing Wang Xian Zhang Qing-Hua Hu Ling-Dong Kong

Fructose-induced hyperinsulinemia is associated with insulin compensative secretion and predicts the onset of type 2 diabetes. In this study, we investigated the preservation of dietary flavonoid quercetin on pancreatic β -cell mass and function in fructose-treated rats and INS-1 β -cells. Quercetin was confirmed to reduce serum insulin and leptin levels and blockade islet hyperplasia in fructo...

2017
Yasaman Mirdamadi Ursula Bommhardt Alexander Goihl Karina Guttek Christos C. Zouboulis Sven Quist Harald Gollnick

Hyper-glycemic food increases insulin-like growth factor 1 (IGF-1) and insulin signaling and regulates endocrine responses and thereby may modulate the course of acne. Inflammation and adaptive immune responses have a pivotal role in all stages of acne. Recent hypothesis suggests that hyperglycemic food reduces nuclear forkhead box-O1 (FoxO1) transcription factor and may eventually induces acne...

2014
Giulia Paroni Davide Seripa Andrea Fontana Grazia D’Onofrio Carolina Gravina Maria Urbano Leandro Cascavilla Fabio Pellegrini Antonio Greco Alberto Pilotto

OBJECTIVE Acetylcholinesterase inhibitors (AChEIs) may reduce the oxidative stress in brain of Alzheimer's disease (AD) patients. Forkhead box O1 (FOXO1) protein has been reported as the link between oxidative stress and AD. We evaluated a potential association between FOXO1 gene locus and the response to AChEI treatment in patients with sporadic AD. METHODS In this prospective study, 109 Cau...

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