This curve has the points (1 : 0 : 0) and (0 : 1 : 0) at infinity over any field. The affine equation is XY +Y +X = 0. The origin is a point of this curve. If (x, y) ∈ F8 is a point of this curve with nonzero coordinates, then x = 1. So 0 = xy + y + x = xy + xy + x = x[(xy) + (xy) + 1]. Let t = xy. Then t + t+ 1 = 0. So the Klein quartic has 3.7 = 21 rational points over F8 with nonzero coordin...

Here we describe a new approach for the generation of heme-peroxo-Cu compounds, using a "naked" complex synthon, [(F8)Fe(III)-(O2(2-))-Cu(II)(MeTHF)3](+) (MeTHF = 2-methyltetrahydrofuran; F8 = tetrakis(2,6-difluorophenyl)porphyrinate). Addition of varying ligands (L) for Cu allows the generation and spectroscopic characterization of a family of high- and low-spin Fe(III)-(O2(2-))-Cu(II)(L) comp...

Dissection of pleiotropic effects of missense mutations, rarely investigated in inherited diseases, is fundamental to understanding genotype-phenotype relationships. Missense mutations might impair mRNA processing in addition to protein properties. As a model for hemophilia A, we investigated the highly prevalent F8 c.6046c>t/p.R2016W (exon 19) mutation. In expression studies exploiting lentivi...

Heat stress is a major production constraint of wheat in South Asia, particularly the Gangetic plains India and Bangladesh. The leaf chlorophyll status key determinant for high rate photosynthesis under stress. present experiments included 238 genotypes 2016-2017 321 2017-2018 optimum heat conditions. Subsequently, set 100 selected on basis susceptibility index was evaluated 2018-2019 condition...

Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain and discomfort which are having shorter half life (1.1hour) with the dose administration of 3-4 times a day. The aim of the study was to prepare and evaluate the Chlorzoxazone sustained release tablets in order to reduce the dose frequency and to improve the patient compliance. The tablets were...

Solid lipid nanoparticle (SLNs) formulae were utilized for the release of 5-flurouracil (5-FU) inside the colonic medium for local treatment of colon cancer. SLNs were prepared by double emulsion-solvent evaporation technique (w/o/w) using triglyceride esters, Dynasan™ 114 or Dynasan™ 118 along with soyalecithin as the lipid parts. Different formulation parameters; including type of Dynasan, so...

Current treatment of hemophilia A (HemA) patients with repeated infusions of factor VIII (FVIII; abbreviated as F8 in constructs) is costly, inconvenient, and incompletely effective. In addition, approximately 25 % of treated patients develop anti-factor VIII immune responses. Gene therapy that can achieve long-term phenotypic correction without the complication of anti-factor VIII antibody for...