The aim of this work was to establish a novel polymeric mixed micelle composed of Pluronic P105 and F127 copolymers loaded with the poorly soluble antitumor drug docetaxel (DTX) against Taxol-resistant non-small cell lung cancer. A central composite design was utilized to optimize the preparation process, helping to improve drug solubilization efficiency and micelle stability. Prepared by a thi...

Xerosis is a common skin condition as well key aspect of number diseases associated to hereditary and acquired conditions. The objective this study was formulate evaluate the pluronic lecithin organogel containing natural moisturizing agents for topical application. Different formulations organogels were prepared by using Pluronic F127, Lecithin, Vitamin E, Aloe vera, water, sorbic acid, potass...

ABSTRACT The objective of this study was to develop a novel subgingival sustained-release system for local delivery bioactive minocycline hydrochloride periodontal disease treatment in dogs. incorporated the Minocycline hydrochloride-Calcium-Dextran sulfate sodium into thermoresponsive Pluronic F127 hydrogel. sustained release from up 10 days and kinetics fit power law model. medium had signifi...

Abstract: This study aimed to evaluate DOX∙HCl loaded P(DLLA-CO:60:40) nanoformulations with a copolymer of F127 as potential drug delivery system for cancer. DOX ∙ HCl was encapsulated in Poly DL-lactic acid co castor oil 60:40, P(DLLACO: 60:40) polymer the copolymer/stabilizer Pluronic® F127. The mean diameter cylindrical rod shape nanoformulation particles 248±2.4-260±3.2 nm an acceptable po...

In this contribution, we apply a soft-template-assisted hydrothermal route using polyethylene-polypropylene glycol (F127) as soft-template agent and biomass batatas carbon precursor to synthesis novel mesoporous biochar (HMC-800) for adsorptive removal of tetracycline (TC) from wastewater. We use the prepared without F127 direct pyrolytic comparison. The physicochemical properties all studied s...

Curcumin nanoparticles of less than 50 nm in diameter are accessible using a continuous flow microfluidic rotating tube processor (RTP) under scalable conditions, at room temperature. A mixture of DDAB and Pluronic F127 renders higher stability of the curcumin nanoparticles in physiological pH 7.4 for up to eight hours. The nanoparticles have enhanced cytotoxicity in estrogens receptor negative...