The pain receptor transient receptor potential vanilloid type 1 (TRPV1) has been reported as one of the key components in the pain pathway. Activation of the receptor causes a Ca2+ influx with secondary effects leading to neurogenic inflammation. Here we report specific activation of TRPV1 by detergent-containing hygiene products measured as intracellular Ca2+ influxes in stably TRPV1-expressin...

Objective To assess the clinical safety and tolerability of a novel MGO Manuka Honey microemulsion (MHME) eye cream for the management of blepharitis in human subjects. Methods and analysis Twenty-five healthy subjects were enrolled in a prospective, randomised, paired-eye, investigator-masked trial. The MHME eye cream (Manuka Health New Zealand) was applied to the closed eyelids of one eye (...

Dust storms are meteorological hazards associated with several adverse health impacts including eye irritations, respiratory and cardiovascular disorders, vehicular road accidents due to poor visibility. This study investigated relations between admissions from a large, public hospital that serves people living in Northern Cape Free State provinces, South Africa during 2011 2017, variables (tem...

QSAR models are frequently used to investigate and predict the toxicological effects of chemicals. Building QSAR models of the eye irritation potential of cationic surfactants is difficult, as the mechanism of action of these surfactants is still not fully understood. This report describes a data driven QSAR model to predict Maximum Average Scores (MAS in accordance to Draize) for cationic surf...

Diabetes is a disease that affects the body’s ability to produce or use insulin effectively to control blood sugar (glucose) levels. DM is a chronic metabolic disorder usually genetic [1,2]. The global diabetes mellitus evidence predicts that 6.4 % of the world population are affecting 286 million adults in 2010 by 2030 is predicted to increase about 7.6 % affecting about 439 million of adults ...

We evaluated CO levels as an index of cigarette smoke in the work place and analyzed diary entries on respiratory symptoms, eye irritation, chest colds and lost days from work due to respiratory illness in 40 passive smokers (nonsmokers chronically exposed to tobacco smoke in the work place) and 40 control subjects (nonsmokers not exposed to tobacco smoke in the work place) matched for age and ...