Epstein-Barr virus (EBV) has been detected in several T- and NK-cell neoplasms such as extranodal NK/T-cell lymphoma nasal type, aggressive NK-cell leukemia, EBV-positive peripheral T-cell lymphoma, systemic EBV-positive T-cell lymphoma of childhood, and chronic active EBV infection (CAEBV). However, how this virus contributes to lymphomagenesis in T or NK cells remains largely unknown. Here, w...

BACKGROUND/AIMS Killer inhibitory receptors (KIR) have a modulating effect on the cytotoxic functions of natural killer (NK) cells and T cells. Because lymphoma cells often have the same receptors as their non-neoplastic counterparts, this study investigated the expression of KIR on well defined groups of NK and T cell lymphomas, with and without a cytotoxic phenotype, from different sites of o...

Mature T-cell and natural killer (NK)-cell neoplasms (Table 1) represent a heterogeneous spectrum of post-thymic T-celland NK-cell-derived malignancies. They represent 12% of all nonHodgkin lymphomas (NHLs). Significant geographic variation is noted with increased prevalence of select subtypes [i.e. adult T-cell leukemia/lymphoma (ATLL) and extranodal NK/T-cell lymphoma, nasal type] seen in Asi...

The contribution of Epstein-Barr virus (EBV) to the development of specific types of benign lymphoproliferations and malignant lymphomas has been extensively studied since the discovery of the virus over the last 50 years. The importance and better understanding of the EBV-associated lymphoproliferative disorders (LPD) of B, T or natural killer (NK) cell type has resulted in the recognition of ...

Extra nodal NK/T cell lymphoma, 'nasal type' is a rare clinicopathological entity. The prevalence of nasal lymphoma is estimated at 0.17-1.5% for all non -Hodgkin's lymphomas (NHL), of which 45% originate from the NK/T cell. It is more commonly encountered in Asian countries. The main clinical features are nasal congestion and epistaxis due to local aggressive destruction. It has a distinct imm...

BACKGROUND A growing number of studies demonstrate the utility of (18)fluoro-2-deoxyglucose positron emission tomography (FDG-PET) in the management of malignant lymphoma. The results of FDG-PET, however, have not been studied extensively for T-cell and natural killer (NK)-cell neoplasms. PATIENTS AND METHODS We retrospectively evaluated pretreatment FDG-PET scans in 41 patients with T/NK-cel...

Nasal type extranodal NK/T-cell lymphoma is a distinct entity according to the World Health Organization classification. Although 60% to 90% of patients with this disease present with a destructive mass in the midline facial tissues, it may also primarily or secondarily involve extranasal sites, like the skin. We report the case of a 77-year-old patient that came to our department with erythema...

BACKGROUND/AIMS Although the incidence of T-cell non-Hodgkin's lymphoma (NHL) is higher in Far East Asia than in Western countries, its incidence and clinical course in Korea are not well-defined. Therefore, we assessed the relative frequency and clinical features of T-cell NHL in Korea. METHODS We performed a retrospetcive analysis of 586 patients with NHL. RESULTS 101 (17.2%) had T-cell N...

BACKGROUND Extranodal nasal-type NK/T-cell lymphoma is a rare and severe disease. Considering the rarity of this lymphoma in Europe, we conducted a multicentric retrospective study on nasal-type NK/T cell lymphoma to determine the optimal induction strategy and identify prognostic factors. METHODS Thirty-six adult patients with nasal-type NK/T-cell lymphoma were recruited and assessed. In tot...

Objective: Nasal extranodal NK/T-cell lymphoma is a rare aggressive lesion, characterized by a destructive process of the upper respiratory tract that has an unusual and rapid evolution. Diagnosis is often difficult and requires expert clinical examination and analysis of biopsies using immunohistochemistry. Case report: 34 years-old man with no relevant medical history, presented with an asymp...