"Burned-out" testicular tumor is a rare clinical entity. The term "burned-out" actually represents a spontaneously and completely regressed testicular tumor that manifests itself by metastasis to retroperitoneal region and mediastinal, supraclavicular, cervical and axillary lymph nodes. This is a different entity than primary extragonadal testicular tumors and is seen more rarely. Here we prese...

Gonadal and extragonadal sperm reserves were determined in twenty sexually matured domesticated African greater cane rats. Mean (+/-SD) sperm numbers in testes and epididymides were 150.40+/-12.93x10(9) and 259.33+/-13.68x10(9), respectively. The mean epididymal distribution of spermatozoa was found as follows: 67.53+/-12.43x10(9) in caput, 89.10+/-13.20x10(9) in corpus, and 102.70 +/-13.71x10(...

This review covers the management of patients once they have been diagnosed with a germ cell tumor. We take note of the European Society for Medical Oncology (ESMO) guidelines [1, 2] and European Germ Cell Cancer Consensus Group report [3] and expand on controversial areas where more than one management option exists. Although we will only discuss testicular germ cell tumors, the same principle...

BACKGROUND Family history is among the few established risk factors for testicular germ cell tumor (TGCT). Approximately 1.4% of newly diagnosed TGCT patients report a positive family history of TGCT. Sons and siblings of TGCT patients have four- to six fold and eight- to tenfold increase in TGCT risk, respectively. In twins of men with TGCT the relative risk of testicular cancer is 37.5 (12.3-...

OBJECTIVE To explore the associations between semen characteristics and subsequent risk of testicular cancer. DESIGN Cohort study. PARTICIPANTS 32 442 men who had a semen analysis done at the Sperm Analysis Laboratory in Copenhagen during 1963-95. MAIN OUTCOME MEASURE Standardised incidence ratios of testicular cancer compared with total population of Danish men. RESULTS Men in couples ...

There is a growing awareness that androgens and estrogens have general metabolic roles that are not directly involved in reproductive processes. These include actions on vascular function, lipid and carbohydrate metabolism, as well as bone mineralization and epiphyseal closure, in both sexes. In postmenopausal women, as in men, estrogen is no longer solely an endocrine factor, but instead is pr...

BACKGROUND Mediastinal thymic seminomas are rare male germ cell tumors with extragonadal origin that appear predominately with a cystic appearance. CASE PRESENTATION A 22-year-old male was referred to our department for further investigation of a mediastinal mass discovered incidentally during routine chest X-ray. The patient has denied any symptoms including dyspnea, chest pain, cough, fever...