The field of extracellular vesicles (EVs) has seen a tremendous paradigm shift in the past two decades, from being regarded as cellular waste bags to considered essential mediators intercellular communication. Their unique ability transfer macromolecules across cells and biological barriers made them rising star drug delivery. Mounting evidence suggests that EVs can be explored efficient delive...

Extracellular Vesicles, including exosomes, are small membrane fragments released from many cell types, like Mesenchymal Stem Cells (MSCs). They were recognized as a mechanism of intercellular communication. They can transfer proteins, lipids and nucleic acids to other cells. Thus, they have many physiological (angiogenesis, coagulation and tissue repair, etc.) and pathological (e.g. in autoimm...

Extracellular vesicles (EVs) play important roles in the diagnosis and treatment of diseases because its lavish bioinformatic molecular contents. However, how to separate plentiful extracellular a short time with high consistency is still problem. Here, we’d like introduce an automated capturing machine named EVenrich (Extracellular Vesicles Enrichment) that helps realize EVs biosamples high-th...

Extracellular vesicles are membrane micro/nanovesicles secreted by many cell types into the circulation and the extracellular milieu in physiological and pathological conditions. Evidence suggests that extracellular vesicles, known as matrix vesicles, play a role in the mineralization of skeletal tissue, but emerging ultrastructural and in vitro studies have demonstrated their contribution to c...

BACKGROUND Protein secretion is a fundamental process in all living cells. Gluconeogenic enzymes are secreted when Saccharomyces cerevisiae are grown in media containing low glucose. However, when cells are transferred to media containing high glucose, they are internalized. We investigated whether or not gluconeogenic enzymes were associated with extracellular vesicles in glucose-starved cells...

Background Spinal cord injury (SCI) is defined as traumatic damage to the spinal cord, affecting over three million patients worldwide, and there still no treatment for injured itself. In recent years, immunology research on SCI has been published in various journals. Methods To systematically analyze hotspots dynamic scientific developments of SCI, we conducted a bibliometric knowledge map ana...

The discovery that the cells communicate through emission of vesicles has opened new opportunities for better understanding of physiological and pathological mechanisms. This discovery also provides a novel source for non-invasive disease biomarker research. Our group has previously reported that hepatocytes release extracellular vesicles with protein content reflecting the cell-type of origin....

The mechanisms of action extracellular miRNAs are given in the scientific review. To write article, information was searched using Scopus, Web Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, Cochrane Library databases. authors state that generated by producer cells and then packaged vesicles delivered to other functionally active structures. Extracellular transport miRNA a para...

Background Many bacterial components in indoor dust can evoke inflammatory pulmonary diseases. Bacteria secrete nanometer-sized vesicles into the extracellular milieu, but it remains to be determined whether bacteria-derived extracellular vesicles in indoor dust are pathophysiologically related to inflammatory pulmonary diseases. We evaluated whether extracellular vesicles (EV) in indoor air ar...

Cover Illustration: Electron micrograph showing an area near the interaction sites between Iba1-immunostained microglial cell (shaded in violet) and surface of a motor neuron at spinal cord ventral horn red) following sciatic nerve transection. The extracellular space is delimited yellow. Extracellular multilamellar bodies vesicles derived from degenerating afferent synaptic boutons are seen in...