understanding the function of trichoderma species in the control of phytophthora drechsleri in pistachio orchards is very important.  in this study, the effects of liquid extra-cellular secretions and volatile compounds secreted by 27 isolates of trichoderma harzianum, t. crassum, t. koningii, t.aureoviride, t. asperellum, t. brevicompactum, t.longibrachiatum and t. virens were investigated on ...

Cardiovascular disease poses a major health care burden in the Western world. Following myocardial injuries, ventricular remodelling and dysfunction ensue, which can eventually culminate in heart failure. An important event in left ventricular (LV) remodelling is alteration of the extracellular matrix (ECM) integrity, the structural network that interconnects the myocardial components. The crit...

OBJECT Antiangiogenic treatments are beginning to give promising outcomes in many vascular diseases including tumor angiogenesis. In this current study the antiangiogenic and pro-apoptotic actions of α1(IV)NC1 and its N- and C- peptides α1S1(IV)NC1, α1S2(IV)NC1 were investigated in-vitro and in-vivo. STUDY METHOD Endothelial cells (ECs) were treated with α1(IV)NC1, α1S1(IV)NC1, α1S2(IV)NC1 an...

Dendritic cells (DC) are antigen presenting cells (APC) with the unique ability to initiate an immune response. Immature DC are localized in peripheral tissues where they exert a sentinel function for incoming antigens (Ag). After Ag capture and exposure to inflammatory stimuli DC undergo maturation and migrate to regional lymph nodes where the presentation of antigenic peptides to T lymphocyte...

Extracellular matrix plays a dynamic role during the process of wound healing, embryogenesis and tissue regeneration. Caudal fin regeneration in zebrafish is an excellent model to study tissue and skeletal regeneration. We have analyzed the expression pattern of some of the well characterized ECM proteins during the process of caudal fin regeneration in zebrafish. Our results show that a transi...

Dehong Zeng, Aldo Ferrari, Jens Ulmer, Alexey Veligodskiy, Peter Fischer, Joachim Spatz, Yiannis Ventikos, Dimos Poulikakos, Ruth Kroschewski * Laboratory of Thermodynamics for Emerging Technologies, ETH Zurich, 8092 Zürich, Switzerland # Institute of Biochemistry, ETH Zurich, Schafmattstr. 18, 8093 Zürich, Switzerland § Max-Planck-Institute for Metals Research & University of Heidelberg Dept. ...

Pancreatic ductal adenocarcinoma [PDAC] continues to be associated with a dismal prognosis with 5-year survival rates consistently less than 5% [1]. One of the main histopathological features of PDAC is the abnormal deposition of stromal fibrosis, also known as desmoplasia. It constitutes the tumor microenvironment in which various sub-populations of the innate and adaptive immune system are di...

Fetal liver is the major embryonic hematopoietic organ and is extrinsically colonized by circulating hematopoietic stem cells (HSCs). Integrin beta-1 expression on HSCs is crucial for colonization, suggesting that interaction of Integrin beta-1 with extra-cellular matrix (ECM) factors promotes HSC adherence to fetal liver. However, little is known about how ECM production is regulated in fetal ...