The use of service-oriented architectures based on web services in the manufacturing layer of industrial enterprises enables vertical integration and promises increased interoperability. Unfortunately, the differing execution patterns—cyclic execution on programmable logic controllers vs. on-demand execution on industrial PCs—complicate the use of web services in the manufacturing layer. This p...

The Centers for Disease Control and Prevention’s (CDC’s) National En­ vironmental Public Health Tracking Network (Tracking Network) expands con­ tent and functionality every year. This year, two new datasets were added: pesticide expo­ sure and 70 years of prospective climate data. These represent two important environmen­ tal public health concerns. In 2012, pesticides were the 10th leading ca...

Farmed landscapes are engineered for productivity, and research suggests they contribute a disproportionate share of inorganic C to the Mississippi River and Gulf of Mexico. Here we use alkalinity and total organic C (TOC) measurements collected from the Raccoon River of Iowa to (i) evaluate inorganic and organic C concentrations and export patterns, (ii) compare current trends to historical co...

To examine the relationship between folding and export competence by the twin-arginine translocation (Tat) pathway we analyzed the subcellular localization of fusions between a set of eight putative Tat leader peptides and alkaline phosphatase in isogenic Escherichia coli strains that either allow or disfavor the formation of protein disulfide bonds in the cytoplasm. We show that export by the ...

in this study, which is in the course of help to the development of the export and the export marketing in the realm of the food industries, ten factors including the firms size, the export experience, the export stimuli, the export problems, the competitive advantages, the export commitment, the adaptation product strategy, the adaptation pricing strategy, direct export channel and overseas ad...

The TREX complex (TREX) plays key roles in nuclear export of mRNAs. However, little is known about its transcriptome-wide binding targets. We used individual cross-linking and immunoprecipitation (iCLIP) to identify the binding sites of ALYREF, an mRNA export adaptor in TREX, in human cells. Consistent with previous in vitro studies, ALYREF binds to a region near the 5' end of the mRNA in a CBP...

Beclin 1 encodes a Bcl-2-interacting coiled-coil protein with autophagy and tumor suppressor function and is monoallelically deleted in 40–75% of sporadic human breast and ovarian cancers. Beclin 1 contains a leucinerich nuclear export signal motif raising the possibility that its autophagy and/or tumor suppressor function may require regulated, CRM1-dependent, nucleocytoplasmic transport. In t...

Eukaryotic mRNAs undergo a cycle of transcription, nuclear export, and degradation. A major challenge is to obtain a global, quantitative view of these processes. Here we measured the genome-wide nucleocytoplasmic dynamics of mRNA in Drosophila cells by metabolic labeling in combination with cellular fractionation. By mathematical modeling of these data we determined rates of transcription, exp...