نتایج جستجو برای: exemestane

تعداد نتایج: 576  

2017
Jingwen Zhang Yanhong Huang Changyi Wang Yuanfang He Shukai Zheng Kusheng Wu

BACKGROUND Endocrine therapy was recommended as the preferred first-line treatment for hormone receptor-positive (HR+, i.e., ER+ and/or PgR+), human epidermal growth factor receptor-2-negative (HER2-) postmenopausal advanced breast cancer (ABC), but which endocrine monotherapy is optimal lacks consensus. We aimed to identify the optimal endocrine monotherapy with a network meta-analysis. METH...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2001
P E Goss

With recent results showing letrozole and anastrozole to be superior to tamoxifen as initial therapy for advanced disease, the aromatase inhibitors are poised to establish their place in the adjuvant therapy of postmenopausal receptor-positive breast cancer. A review of the rationale, design, and preliminary results of the ongoing adjuvant trials that include aromatase inhibitors will be presen...

Journal: :Journal of Postgraduate Medicine 2007

Journal: :Breast 2013
Meredith M Regan Olivia Pagani Gini F Fleming Barbara A Walley Karen N Price Manuela Rabaglio Rudolf Maibach Barbara Ruepp Alan S Coates Aron Goldhirsch Marco Colleoni Richard D Gelber Prudence A Francis

OBJECTIVES In 2003 the International Breast Cancer Study Group (IBCSG) initiated the TEXT and SOFT randomized phase III trials to answer two questions concerning adjuvant treatment for premenopausal women with endocrine-responsive early breast cancer: 1-What is the role of aromatase inhibitors (AI) for women treated with ovarian function suppression (OFS)? 2-What is the role of OFS for women wh...

2017
Tomás Reinert Carlos H. Barrios

We reviewed randomized phase II/III trials comparing first- or second-line endocrine therapy as monotherapy or in combination with targeted therapies for treatment of postmenopausal patients with hormone receptor-positive advanced breast cancer. First-line was defined as treatment for endocrine therapy-naïve advanced breast cancer or advanced disease treated with endocrine therapy in the adjuva...

Journal: :Breast Cancer Research and Treatment 2009

Journal: :Cellular Physiology and Biochemistry 2017

Journal: :Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2015
Vered Stearns Judith-Anne W Chapman Cynthia X Ma Matthew J Ellis James N Ingle Kathleen I Pritchard G Thomas Budd Manuela Rabaglio George W Sledge Aurélie Le Maitre Jessica Kundapur Pedro E R Liedke Lois E Shepherd Paul E Goss

PURPOSE Treatment-emergent symptoms with adjuvant tamoxifen and aromatase inhibitors (AIs) have been associated with superior recurrence-free survival (RFS). We hypothesized that MA.27 anastrozole- or exemestane-treated patients with new or worsening vasomotor and/or joint symptoms would have improved RFS. PATIENTS AND METHODS MA.27 randomly assigned 7,576 postmenopausal women with breast can...

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