In patients with breast cancer, markers of aggressiveness such as dysregulation of the insulin-like growth factor receptor (IGF1R) system and E-cadherin loss are commonly observed. Reduced IGF1R expression is correlated with decreased E-cadherin levels and increased cell motility. We assessed IGF1R and E-cadherin expression in circulating tumor cells (CTCs) in patients with breast cancer. Perip...

AIMS Breastfeeding significantly benefits mothers and infants. We aimed to identify the determinants of its successful initiation. METHODS A retrospective study of 1893 mothers delivering healthy term singletons at a Swiss university hospital from 1/2008 to 3/2009 determined the associations between multiple breastfeeding and early postpartum parameters by univariate and multiple regression a...

BACKGROUND Effects of prenatal iron supplementation on maternal postpartum iron status and early infant iron homeostasis remain largely unknown. OBJECTIVE We examined iron absorption and growth in exclusively breastfed infants in relation to fetal iron exposure and iron status during early infancy. DESIGN Longitudinal, paired iron-absorption (⁵⁸Fe) studies were conducted in 59 exclusively b...

Exclusive breast-feeding until 6 months is advised by the WHO as the best practice to feed infants. Yet, some studies have suggested a gap between energy requirements and the energy provided by human milk for many infants at 6 months. In order to assess the adequacy of WHO recommendations in 6-month-old Senegalese lactating infants, a comprehensive study was designed to measure human milk intak...

OBJECTIVE To investigate the effect of public hospitals in Hong Kong not accepting free infant formula from manufacturers on in-hospital formula supplementation rates and breast-feeding duration. DESIGN Prospective cohort study. SETTING In-patient postnatal units of four public hospitals in Hong Kong. SUBJECTS Two cohorts of breast-feeding mother-infant pairs (n 2560). Cohort 1 (n 1320) w...

INTRODUCTION The hormone melatonin regulates the sleep and this pineal hormone is synthesized in the organism from the amino acid tryptophan. It is known that breast-fed babies have better sleep patterns and a better entrained sleep/wake cycle than bottle-fed babies (adapted formula). OBJECTIVE To compare the circadian rhythm of 6-sulfatoxymelatonin (aMT6s)--the metabolite of melatonin excret...

OBJECTIVE We examined whether breast-feeding, and in particular exclusive breast-feeding, was associated with maternal weight and body composition changes at 4 months postpartum independently of other maternal variables. DESIGN Prospective longitudinal study. Women were recruited in the first trimester after an ultrasound examination confirmed an ongoing singleton pregnancy. Weight and body c...

We report the anti-breast cancer stem cell (CSC) properties of a series Group 10-bis(azadiphosphine) complexes 1–3 under exclusively three-dimensional culture conditions. The breast CSC mammosphere potency is dependent on 10 metal present, increasing in following order: 1 (nickel complex) <2 (palladium <3 (platinum complex). Notably, 3 reduces formation and size mammospheres to greater extent t...

In order to know the associations between multifocality (MF), without related multicentricity (MC), and common clinical and biological parameters, and posterior influence in breast carcinoma behavior, we have developed this study. 816 successive women affected from invasive breast carcinomas, of which 96 were multifocal and 720 nonmultifocal were included in the study. We considered age, size, ...

Metastasis is a critical event affecting breast cancer patient survival. To identify molecules contributing to the metastatic process, we analysed The Cancer Genome Atlas (TCGA) breast cancer data and identified 41 genes whose expression is inversely correlated with survival. Here we show that GABAA receptor alpha3 (Gabra3), normally exclusively expressed in adult brain, is also expressed in br...