Aim: This study was aimed to review and establish the practice of exchange transfusion (ET) with whole blood reconstituted (WBR) in hemolytic disease of newborn (HDN). Objectives: To observe fall in indirect serum bilirubin, correction of anemia and comparison with related studies. Background: Hemolytic disease of the Newborn is characterized by presence of IgG antibodies in maternal circulatio...

different treatments. Saunders carries out an exchange transfusion routinely if the patient remains in deep coma after 24 hours. In another personal series (from the Hospital Beaujon, Clichy) the results were quite different.1" Between 1952 and 1969 77 patients with severe viral hepatitis were seen, of whom 75 were in coma. Of 56 patients treated conservatively 13 survived, whereas there were n...

Wood, Ben, Comley, Ann, and Sherwell,Janet (1970). Archives of Disease in Childhood, 45, 59. Effect of additional albumin administration during exchange transfusion on plasma albumin and reserve albumin-binding capacity. A total of 33 infants undergoing exchange transfusion for hyperbilirubinaemia was divided into two albumin-treated groups and a control group. Both albumin-treated groups showe...

Neonatal hemochromatosis (NH) is an acute liver disease associated with both hepatic and extrahepatic iron deposition and is a leading cause of neonatal liver transplantation. The concept that NH is an alloimmune disease has led to the emergence of a new treatment approach utilizing exchange transfusion and intravenous immunoglobulin therapy. We present a two-day old neonate with progressive li...

An 11-month-old patient with idiopathic cardiomyopathy was scheduled for orthotopic heart transplantation. A perioperative exchange transfusion was performed because of elevated panel reactive antibody levels. This process was accomplished in the operating room prior to instituting cardiopulmonary bypass using a modified cardiopulmonary bypass circuit. In preparation for the procedure, the card...

In a previous study by Anderson, Smith and Walker (1961), it was observed that in four out of 100 infants undergoing exchange transfusion for haemolytic disease of the newborn, a rise of blood pyruvate occurred during the procedure. It was suggested that the rise of blood pyruvate might be due either to the metabolic action of citrate or glucose, and that this biochemical change might be relate...

In eight patients with polycythaemia secondary to hypoxic lung disease 10 elective exchange transfusions were performed to reduce red cell mass, packed cell volume (P.C.V.), and whole blood viscosity. The rationale for reducing P.C.V. is discussed. It is concluded that patients with P.C.V. of 60% or over will benefit from exchange transfusion and that most patients with P.C.V. over 50% and true...

Polyhemoglobin (polyHb) is currently being assessed in phase III trials under various formulations. At present, none contain clotting factors or platelet substitutes to aid in hemostasis. We have prepared a novel blood substitute that is an oxygen carrier with platelet-like activity. This is formed by crosslinking fibrinogen to hemoglobin to form polyhemoglobin-fibrinogen (polyHb-Fg). This was ...