BACKGROUND In vitro studies suggest that mediators of systemic inflammatory response syndrome are generated in the course of hemolytic transfusion reactions. Evidence for the in vivo significance of these findings is given by the present clinical and laboratory analysis of a severe delayed hemolytic transfusion reaction (DHTR). CASE REPORT A 67-year-old patient (blood group O, D-negative) wit...

Milner, R. D. G., Fekete, M., Assan, R., and Hodge, J. S. (1972). Archives of Disease in Childhood, 47, 179. Effect of glucose on plasma glucagon, growth hormone, and insulin in exchange transfusion. Exchange transfusions were performed on term normal-for-dates, and term small-for-dates infants using blood preserved with acid citrate and glucose or acid citrate alone. The plasma concentrations ...

Hematocrit (Hct) of awake hamsters and CD-1 mice was acutely increased by isovolemic exchange transfusion of packed red blood cells (RBCs) to assess the relation between Hct and blood pressure. Increasing Hct 7-13% of baseline decreased mean arterial blood pressure (MAP) by 13 mmHg. Increasing Hct above 19% reversed this trend and caused MAP to rise above baseline. This relationship is describe...

BACKGROUND AND OBJECTIVES There is a huge need for blood transfusion in the newborn particularly due to the reduced marrow activity in the neonatal period. Despite widely use of blood products in the neonatal period, there is paucity of local data on the pattern, indications and reactions to blood transfusions in Nigerian newborns. This study evaluates the blood transfusion indications and patt...

OBJECTIVE To determine the role of intravenous administration of human albumin prior to blood exchange in term neonates for reduction of total serum bilirubin (TSB). DESIGN Randomized controlled trial. SETTING Neonatal Unit of Nemazee Hospital, affiliated with Shiraz University of Medical Sciences, southern Iran. PATIENTS Fifty out-born term neonates with gestation age <37 weeks, birth we...

background :severe neonatal hyperbilirubinemia is associated with significant morbidity and mortality. this study was conducted to investigate the causes of severe hyperbilirubinemia leading to exchange transfusion (et) from march 2009 to march 2011 in bahrami children hospital, tehran, iran in order to establish guidelines to prevent profound jaundice & et.   methods : 94 neonates underwent et...

The large increase in cerebral blood flow (CBF) after fluorocarbon (FC)-exchange transfusion is thought to be caused by low oxygen content, decreased viscosity, or direct vasodilatory effect of the FC perfusate. The aim of this study was to determine whether nitric oxide (NO)-mediated vasorelaxation is increased in FC-perfused hemoglobin (Hb)-free cats because NO is not scavenged by Hb. We meas...

background :although transfusion is a common procedure for treating anemia of prematurity, there is no specific protocol for blood transfusion in premature newborns. so in this study we investigate whether application of a strict protocol has any statistically significant effect on reduction of blood transfusion.   methods : in this study, first group admitted in nicu during 2005 - 2006 and the...

background: it is not clear whether the use of volumetric peristaltic infusion pumps, affect the quality of the erythrocytes during packed cell transfusion or not. in the present study in vitro quality of red blood cells was assessed after using this type of infusion pumps in a prospective study. materials and methods: in this study 60 units of packed red cells were examined before and after pa...

the aim of this study was to evaluate the immune system and lymphocyte function in 41 iranian β-thalassemic patients and 50 controls, ages ranging from 2 to 18 years. the patients consisted of 20 splenectomized and 21 non-splenectomized patients. they were treated with desferal, and had received repeated blood transfusion. laboratory investigations included measurement of total t lymphocytes, a...