Seaweed and soy foods are consumed daily in Japan, where breast cancer rates for postmenopausal women are significantly lower than in the West. Likely mechanisms include differences in diet, especially soy consumption, and estrogen metabolism. Fifteen healthy postmenopausal women participated in this double-blind trial of seaweed supplementation with soy challenge. Participants were randomized ...

The National Comprehensive Cancer Network (NCCN) first published the NCCN Breast Cancer Treatment Guidelines in 1996. The Guidelines address the treatment of all stages of breast cancer across the spectrum of patient care and have been updated yearly. Adjuvant therapy for breast cancer has undergone an especially rapid evolution over the past few years. Therefore, the NCCN Breast Cancer Guideli...

OBJECTIVES To determine whether magnesium intake from supplemental and dietary sources is associated with bone mineral density (BMD) in older men and women. DESIGN Cross-sectional. SETTING Memphis, Tennessee, and Pittsburgh, Pennsylvania. PARTICIPANTS Two thousand thirty-eight older black and white men and women aged 70 to 79 at baseline enrolled in the Health, Aging and Body Composition ...

background: the preparation of endometrium for embryo reception and implantation are controlled by ovarian hormones. these hormones have distinct cyclical changes during estrus cycle. objective: the aim of this study was to evaluate the changes in morphology and morphometrical indices of endometrium by daily injections of estrogen and progesterone in ovariectomized mouse. materials and methods:...

Diethylstilbestrol (DES) is a potent, synthetic, non-steroidal estrogen that, as the classic example of an endocrine disruptor, exemplifies the damaging potential of xenoestrogens. It was widely prescribed to pregnant women between 1938 and 1971 in the belief that a supplement to natural estrogen production would prevent miscarriages or premature deliveries. However, in 1971 Herbst et al. repor...

Neurotrophic factors are playing vital roles in survival, growth, and function of neurons. Regulation of neurotrophic factors in the brain has been considered as one of the targets in developing drug or therapy against neuronal disorders. Flavonoids, a family of multifunctional natural compounds, are well known for their neuronal beneficial effects. Here, the effects of flavonoids on regulating...

BACKGROUND Adequate intakes of calcium and vitamin D reduce bone loss and fracture risk in the elderly. Other nutrients also affect bone health, and adequate intakes may influence bone turnover and balance. OBJECTIVE We compared the long-term effects on bone turnover markers and calciotropic hormones of a multinutrient supplement, a calcium and vitamin D supplement, and dietary instruction ai...

Hypothesis Elderly breast cancer patients are underdiagnosed and undertreated in our Breast Unit. Patients A total of 87 breast cancer patients aged 70 years or older diagnosed between 2003 and 2007, treated in our Unit, was identified. The data for 3 prospectively chosen age subgroups (aged 70–74, 75–79, and 80 years) were subsequently analyzed. Data were collected regarding the method of dete...

Dietary phytoestrogens are well known to have potential hormonal effects owing to their interaction with estrogen receptors [1]. Abnormalities in reproductive health due to a high intake of phytoestrogens have been reported in several women [2,3]. Interestingly, genistein–a type of phytoestrogen–is known to have estrogenic properties, and various hormonal effects of this compound have been repo...

α Susceptibility to Early Atherosclerosis in Male Mice Is Mediated by Estrogen Receptor Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2004 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.ATV.0000130467.65290.d4 2004;24:1055...