Background: The female breast is subjected to a lifetime of hormonal controls, whose effect is evident at the time of menarche and during the menstrual cycle, pregnancy and lactation. Studies have reported multiple risk factors for breast cancer, some of which are a reflection of hormonally mediated events. The steroid receptors are also served as prognostic factors for evaluating status of mal...

Uterine endometrial cancer (UEC) is an estrogen-related tumor. Succinate and heme metabolism play important roles in the progression of multiple tumors. However, relationship between estrogen, succinate, related regulatory mechanisms remain largely unknown. In this study, we observed that expression aminolevulinate delta synthase 1 (ALAS1) solute carrier family member 38 (SLC25A38) UEC tissues ...

The G-protein-coupled estrogen receptor-1 (GPER-1), also known as GPR30, is a novel estrogen receptor mediating estrogen receptor signaling in multiple cell types. The progress of estrogen-related cancer is promoted by GPER-1 activation through mitogen-activated protein kinases (MAPK), phosphoinositide 3-kinase (PI3K), and phospholipase C (PLC) signaling pathways. However, this promoting effect...

Aims: Breast and ovarian cancers are frequently associated with mutations in genes involved DNA double-strand break (DSB) repair by homologous recombination (HR). Risk factors for breast cancer often linked to estrogen-related pathways. Here, we studied the crosslink between estrogen HR pathway. Methods: We analyzed, using online annotation tolls, enrichment of candidate estrogen-upregulated am...

Objective(s): Traumatic brain injury (TBI) is one of the most common causes of death and disability in modern societies. The role of steroids and melatonin is recognized as a neuroprotective factor in traumatic injuries. This study examined the role of melatonin receptors in the neuroprotective effects of estrogen. Materials and Methods: Seventy female ovariectomized Wistar rats were divided in...

the aim of this study was assessing the adjuvant therapy of exercise on cytokines balance in mice with breast cancer tumor. twenty female balb/c mice were randomly assigned to experimental and control groups. after orientation in the environment, estrogen-receptor dependent breast cancer cells (mc4-l2) were injected to them and experimental group performed endurance training 5 day in week for 6...

OBJECTIVES To investigate the association between smoking and invasive breast cancers characterized by their estrogen receptor status in a large prospective study of mainly premenopausal women. METHODS 112,844 women aged 25-42 years in 1989 were followed 10 years; questionnaire information on medical illnesses and risk factors was collected biennially and information on diet was collected in ...

Two major breast cancer sub-types are defined by the expression of estrogen receptors on tumour cells. Cancers with large numbers of receptors are termed estrogen receptor positive and those with few are estrogen receptor negative. Using genome-wide single nucleotide polymorphism genotype data for a sample of early-onset breast cancer patients we developed a Support Vector Machine (SVM) classif...

Background: The objective of this study is to evaluate combined effect of Thymoquinone (The main active component of black seeds) with Tamoxifen drug on apoptosis of human breast cancer MCF-7 cells (Noninvasive human breast cancer cell line, estrogen receptor positive). Materials and Methods: The human breast cancer MCF- 7 cells were treated with Tamoxifen (2 μM) alone or in combination with Th...