Hypoxia and extracellular acidosis are pathophysiological hallmarks of aggressive solid tumors. Regulation of intracellular pH (pHi) is essential for the maintenance of tumor cell metabolism and proliferation in this microenvironment and key proteins involved in pHi regulation are of interest for therapeutic development. Carbonic anhydrase 9 (CA9) is one of the most robustly regulated proteins ...

Diagnosis of child permanent hearing impairment (PHI) can be made with extreme timeliness compared to the past thanks to improvements in PHI identification through newborn hearing screening programmes. It now becomes essential to provide an effective amplification as quickly as possible in order to restore auditory function and favour speech and language development. The early fitting of hearin...

"We get a new multiplicity result for gradient systems. Here is very particular corollary: Let $\Omega\subset {\bf R}^n$ ($n\geq 2$) be smooth bounded domain and let $\Phi:{\bf R}^2\to R}$ $C^1$ function, with $\Phi(0,0)=0$, such that $$\sup_{(u,v)\in R}^2}\frac{|\Phi_u(u,v)|+|\Phi_v(u,v)|}{1+|u|^p+|v|^p}<+\infty$$ where $p>0$, $p=\frac{2}{n-2}$ when $n>2$.\\ Then, every convex set $S\...

For every N > 0 there exists a group of deficiency less than −N that arises as the fundamental group of a smooth homology 4–sphere and also as the fundamental group of the complement of a compact contractible submanifold of the 4–sphere. A group is the fundamental group of the complement of a contractible submanifold of the n–sphere, n > 4, if and only if it is the fundamental group of a homolo...

The aim of this paper is twofold. Firstly, we will investigate the link between condition for functions $\phi(s)$ from $(\alpha, \beta)$-metrics Douglas type to be self-concordant and k-self concordant, other objective continue recently new introduced \beta)$-metric ([17]): $$ F(\alpha,\beta)=\frac{\beta^{2}}{\alpha}+\beta+a \alpha where $\alpha=\sqrt{a_{ij}y^{i}y^{j}}$ a Riemannian metric; $\b...