introduction: cholesterol and fatty acids are two important components of the lipids. various fatty acids have different effects on plasma lipoproteins. consumption of saturated fatty acids tends to increase total plasma and ldl cholesterol levels. while  polyunsaturated fatty acids reduce both ldl and hdl cholesterol, edible oil rich in monounsaturated fatty acid (mufa) however, tend to lower ...

The human brain is nearly 60 percent fat. We've learned in recent years that fatty acids are among the most crucial molecules that determine your brain's integrity and ability to perform. Essential fatty acids (EFAs) are required for maintenance of optimal health but they can not synthesized by the body and must be obtained from dietary sources. Clinical observation studies has related imbalanc...

The incorporation of (n-3) versus (n-6) fatty acids into membrane lipids is regulated by a number of different processes within the cell. It is generally accepted that a common 6-desaturase uses both linoleate and linolenate as substrates. Desaturation of linoleate and linolenate are generally considered to be the rate limiting steps in the biosynthesis of arachidonate and 20:5(n-3) respectivel...

Bioactives can be defined as: "Constituents in foods or dietary supplements, other than those needed to meet basic human nutritional needs, which are responsible for changes in health status" (Office of Disease Prevention and Health Promotion, Office of Public Health and Science, Department of Health and Human Services in Fed Reg 69:55821-55822, 2004). Although traditional nutrients, such as vi...

Disturbances in fatty acid (FA) metabolism may link chronic psychological stress, endocrine responsiveness, and psychopathology. Therefore, lipidmetabolome-wide responses and their relationshipswith endocrine (cortisol, insulin, and adiponectin) responsiveness to acute stress (AS) were assessed in a primate model of chronic social stress (CS). Compared to controls (not exposed to CS), CS increa...

The aim of this study was to investigate the effect of different penetration enhancers, containing essential fatty acids (EFAs), on the transdermal delivery of flurbiprofen. Evening primrose oil (EPO), vitamin F, and Pheroid technology all contain fatty acids and were compared using a cream-based formulation. This selection was to ascertain whether EFAs solely, or EFAs in a Pheroid delivery sys...

Erik von Elm PLoS Medicine now encourages translations in languages other than English; this decision can only be welcomed. German-speaking readers are pleased by the novelty of a PLoS title written in their language. The Editorial starts with the fi rst line of the well-known German poem “Lorelei” by Heinrich Heine (1797–1856) [1]. This year commemorates the 150th anniversary of his death. Ori...

The essentiality of certain amino acids and certain fatty acids was established for growing rats at about the same time. W.C. Rose at the University of Illinois in the early 1930’s identified 10 essential dietary amino acids for rats. Soon thereafter, these same essential dietary amino acids were confirmed experimentally in growing nonruminant livestock. The fatty acids, linoleic acid (C18:2) a...