Although cell intercalation driven by non-canonical Wnt/planar cell polarity (PCP) pathway-dependent mediolateral cell polarity is important for notochord morphogenesis, it is likely that multiple mechanisms shape the notochord as it converges and extends. Here we show that the recessive short-tailed Ciona savignyi mutation chongmague (chm) has a novel defect in the formation of a morphological...

We identified the Drosophila trio gene, which encodes a Dbl family protein carrying two Dbl homology (DH) domains, each of which potentially activates Rho family GTPases. Trio was distributed along axons in the central nervous system (CNS) of embryos and was strongly expressed in subsets of brain regions, including the mushroom body (MB). Loss-of-function trio mutations resulted in the misdirec...

The functional significance of the actin-binding region at the N terminus of the cardiac myosin essential light chain (ELC) remains elusive. In a previous experiment, the endogenous ventricular ELC was replaced with a protein containing a 10-amino acid deletion at positions 5-14 (ELC1vDelta5-14, referred to as 1vDelta5-14), a region that interacts with actin. 1vDelta5-14 mice showed no discerna...

Cadherin complexes mediate cell-cell adhesion and are crucial for embryonic development. Besides their structural function, cadherin complexes also transduce tension across the junction-actomyosin axis into proportional biochemical responses. Central to this mechanotransduction is the stretching of the cadherin-F-actin-linker α-catenin, which opens its central domain for binding to effectors su...

The SIRT1 deacetylase is one of the best-studied putative mediators of some of the anti-aging effects of calorie restriction (CR), but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies of SIRT1 displayed a shorter median lifespan than wild-type mice on an ad libitum diet. Here, we report that median lifespan extension in CR ...

In Section 2, we begin by presenting most of the up-to-date results in the literature [3, 5, 6, 7, 8, 12] concerning fixed point theory in extension-type spaces. These results are then used to obtain a number of new fixed point theorems, one concerning approximate neighborhood extension spaces and another concerning inward-type maps in extensiontype spaces. Our first result was motivated by ide...

The study assessed farmers’ perception of effectiveness of agricultural extension agents in Anambra State, Nigeria. The population of the study comprised all contact farmers and extension agents in Anambra State. Multi-stage, purposive and simple random sampling techniques were used to select 200 respondents comprising 160 farmers and 40 extension agents. Data for the study were collected throu...

Compartmentalised extension prohibits the uptake of new technology thereby inhibiting agricultural growth. Extension services aimed at increased agricultural growth should have a market-led and evidence-based pluralistic advisory system that is coordinated by the government’s Agricultural and Technical Services division in response to the needs of farmers. This study sought to assess extension ...

We prove a fundamental conjecture of Rubin on the structure local units in anticyclotomic $\mathbb{Z}_p$-extension unramified quadratic extension $\mathbb{Q}_p$ for $p\geq 5$ prime. Rubin's underlies Iwasawa theory deformation CM elliptic curve over field at primes $p$ good supersingular reduction, notably main terms $p$-adic $L$-function. As consequence, we an inequality Birch and Swinnerton-D...