Objective: Epilepsy is a devastating neurological disorder with several cognitive or psychiatric comorbidities, including anxiety, autism spectrum disorder, and depressive disorder. It known that long-term drug treatment in epileptic patients increases the incidence of depression. Thus, epilepsy who later developed symptoms usually require to use antidepressant medication throughout their treat...

INTRODUCTION The effects of escitalopram (10 mg/d) coadministration on plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, were studied in 13 Japanese psychiatric patients and compared with those of paroxetine (10 mg/d) coadministration. METHODS The patients had received 6-24 mg/d of aripiprazole for at least 2 weeks. Patients were randomly allocated to one o...

BACKGROUND/AIMS Polycystic ovary syndrome (PCOS) is associated with insulin resistance, adrenal hyperactivity and decreased mental health. We aimed to investigate the changes in adrenal activity, metabolic status and mental health in PCOS during treatment with escitalopram or placebo. METHODS Forty-two overweight premenopausal women with PCOS and no clinical depression were randomized to 12-w...

The default-mode network (DMN), which comprises medial frontal, temporal and parietal regions, is part of the brain's intrinsic organization. The serotonergic (5-HT) neurotransmitter system projects to DMN regions from midbrain efferents, and manipulation of this system could thus reveal insights into the neurobiological mechanisms of DMN functioning. Here, we investigate intrinsic functional c...

A serotonin (5-HT) transporter (5-HTT; SERT) polymorphism has been associated with depressive states and poor responses to selective serotonin reuptake inhibitors (SSRIs). Given the similar attenuation of SERT activity in SERT+/- mice and in humans with short allele(s) of SERT in its promoter region, it is conceivable that SERT+/- mice offer an adequate model to mimic the human subpopulation wi...

BACKGROUND Huntington's disease (HD) is a neurodegenerative syndrome that leads to marked decline in cognitive functioning along with uncharacteristic body movements called chorea. There exists no therapeutic agent to address the disease.3-Nitropropionic acid (3-NP) which is a suicide inhibitor of succinate dehydrogenase and a well-known experimental model to study Huntington's disease, causes ...

IMPORTANCE Currently, fewer than 40% of patients treated for major depressive disorder achieve remission with initial treatment. Identification of a biological marker that might improve these odds could have significant health and economic impact. OBJECTIVE To identify a candidate neuroimaging "treatment-specific biomarker" that predicts differential outcome to either medication or psychother...

IMPORTANCE Major depressive disorder develops in up to half the patients undergoing treatment for head and neck cancer, resulting in significant morbidity; therefore, preventing depression during cancer treatment may be of great benefit. OBJECTIVE To determine whether prophylactic use of the antidepressant escitalopram oxalate would decrease the incidence of depression in patients receiving p...

IMPORTANCE Mental stress can induce myocardial ischemia and also has been implicated in triggering cardiac events. However, pharmacological interventions aimed at reducing mental stress-induced myocardial ischemia (MSIMI) have not been well studied. OBJECTIVE To examine the effects of 6 weeks of escitalopram treatment vs placebo on MSIMI and other psychological stress-related biophysiological...

Objective: To investigate the effect of treatment with Escitalopram on attentional bias in PD using an ERP dotprobe task of facial expression. Method: Subjects included 25 patients with PD, and 25 controls. Psychopathology was rated in patients with the HAMA at baseline, after 8-week treatments with Escitalopram. EEG was recorded at Oz when participants perform dot-probe task of facial expressi...