We present a kindred of 29 persons affected with erythromelalgia (erythermalgia) in 5 generations. This paper updates the family reported by Burbank et al. [1966]. Patients have symptoms of intermittent intense burning limb pain related to increased skin temperature. No successful treatment has been identified, and the pathogenetic mechanism has not been established. Most affected individuals a...

Introduction To "put your feet up" after a hard day's work is a most pleasant form of relaxation, but for the erythromelalgic patient the phrase has a more sinister meaning. Erythromelalgia (EM) is a disorder characterized by intense burning pain, increased temperature and redness of the skin, particularly of the lower limbs. The symptoms are precipitated by exposure to heat, dependency and exe...

This paper deals with the optimality conditions and dual theory of multi-objective programming problems involving generalized convexity. New classes of generalized type-I functions are introduced for arcwise connected functions, and examples are given to show the existence of these functions. By utilizing the new concepts, several sufficient optimality conditions and Mond-Weir type duality resu...

In this paper, the concept of ∂-quasiconvexity is introduced by using convexifactors. Mond-Weir-type and Schaible-type duals are associated with a multiobjective fractional programming problem, and various duality results are established under the assumptions of ∂-pseudoconvexity and ∂-quasiconvexity.

Erythromelalgia is a rare clinical syndrome characterized by heat, redness and intermittent pain in the extremities, being most frequent the bilateral development in the lower extremities. Local cooling brings relief to symptoms, while heating, physical exercises and use of stockings/socks intensify the discomfort. This condition can be primary or idiopathic or secondary to haematological disor...