The estrogen receptor (ER) α is overexpressed in most breast cancers, and its level serves as a major prognostic factor. It is important to develop quantitative molecular imaging methods that specifically detect ER in vivo and assess its function throughout the entire primary breast cancer and in metastatic breast cancer lesions. This study presents the biochemical and molecular features, as we...

In human breast cancer, estrogen receptor (ER) status of the tumor has prognostic and therapeutic significance. However, facilities to study ER are not widely available to us. We postulated that if there is a correlation between histologic grade and ER status of invasive ductal carcinoma (IDC), it may help predict the ER status of the tumor. Of 8 4 cases of breast carcinoma referred to the ...

Cyclopentenone prostaglandins (PGs) are transported into cells and stimulate the expression of various stress genes, such as that coding for BiP (an ER luminal protein). To reveal the site of action of the PGs for the induction of stress-gene expression, we introduced a fluorescent probe, pyrene, into two types of PG analogue, GIF0010 (a cyclopentenone type) and GIF0037 (a cyclopentanone type) ...

In this thesis, Er doped SiO2/nc-Si multilayer structure a promising material for on-chip silicon light emission devices, is studied in detail. It is demonstrated, for the first time, that infrared Er emission could be enhanced by an Er doped SiO2/nc-Si multilayer structure. It is also determined that energy transfer from nc-Si to nearby Er ions, is responsible for this emission enhancement. Th...

The coarsening kinetics of nanoscale, coherent Al3ð Sc1 xErxÞ precipitates in a-Al during aging of a supersaturated Al–0.06 Sc–0.02 Er (at.%) alloy at 300 C are studied using transmission electron microscopy and local-electrode atom-probe tomography. Erbium and Sc segregate at the precipitate core and shell, respectively. The matrix supersaturations of Er and Sc, as well as the mean precipitate...

Using a polyclonal antibody raised against calreticulin purified and sequenced from maize, we performed an immunocytological study to characterize putative domain-specific subcellular distributions of endoplasmic reticulum (ER)-resident calreticulin in meristematic cells of maize root tip. At the light microscopy level, calreticulin was immunolocalized preferentially at cellular peripheries, in...

in human breast cancer, estrogen receptor (er) status of the tumor has prognostic and therapeutic significance. however, facilities to study er are not widely available to us. we postulated that if there is a correlation between histologic grade and er status of invasive ductal carcinoma (idc), it may help predict the er status of the tumor. of 8 4 cases of breast carcinoma referred to the canc...

We show that measurement of the difference in the transverse energy distribution of leptons and antileptons’ from tt events at hsdron colliders provides an interesting probe of CP violation in the Higgs sector. We predict a CP violating asymmetry at the 10T3 level. Submitted to Physica. Review Letters PACS numbers: 11.30.Er, 12.15.Cc, 13.85.Qk * Work supported by the Departlnent of Energy, cont...

background and objectives: pseudomonas aeruginosa is one of the most important opportunistic pathogens in patients who suffer from immunodeficiency and burns. wound infections caused by p. aeruginosa can rapidly change to systemic and life threatening situation. the aim of this study was to apply florescent in situ hybridization (fish) method for rapid detection of p. aeruginosa in burrn patien...