Often shifts in context, such as changes in budgets, administrations, and warfighter needs, occur more frequently than high-cost space-based system development timelines. In order to ensure the successful development and operation of such systems, designers must balance between anticipating future needs and meeting current constraints and expectations. This paper describes the application of Mu...

Speech analysis is traditionally performed using short-time analysis to extract features in time and frequency domains. The window size for the analysis is fixed somewhat arbitrarily, mainly to account for the time varying vocal tract system during production. However, speech in its primary mode of excitation is produced due to impulse-like excitation in each glottal cycle. Anchoring the speech...

Pitch period and amplitude perturbations are widely used parameters to discriminate normal and voice disorder speech. Instantaneous pitch period and amplitude of glottal vibrations directly from the speech waveform may not give an accurate estimation of jitter and shimmer. In this paper, the significance of epochs (glottal closure instants) and strength of excitation (SoE) derived from the zero...

This research item has investigated the problem space of Mission Planning and Decision Making in order to enable conceptual epochs of MPDM capability to be defined from which priorities for theme research could be identified. It has approached this by considering three view points: recognising the challenges that needs to be addressed by technologies to enable deliberative autonomy, to understa...

In the redshift range 100 ,(1+z) ,137, the cosmic microwave background (CMB) had a temperature of 273–373 K (0–100 °C), allowing early rocky planets (if any existed) to have liquid water chemistry on their surface and be habitable, irrespective of their distance from a star. In the standardΛCDM cosmology, the first star-forming halos within our Hubble volume started collapsing at these redshift...

One of the goals of human functional imaging studies is to interpret brain activation in the context of an individual's subjective experience. However, functional magnetic resonance imaging (fMRI) studies usually employ a block design that consists of multiple epochs of stimulation; this strategy does not readily allow subjective responses to be assessed on a stimulus-by-stimulus basis. To addr...

INTRODUCTION A phase II study of EPOCH chemotherapy in relapsed Hodgkin's disease was performed in 14 patients in a multicenter community setting. Patients and Methods. A total of 14 patients (9 males and 5 females) were included in the study. Ages ranged from 21-72 with a median age of 33. Eleven out of 14 patients had advanced (stage III or IV) disease, but all patients had good performance s...

Of the three factors, age at death, epoch of death, and epoch of birth, one seems almost superfluous. It may nevertheless be worthwhile to include all three in a mortality analysis, allowing for the constraints that the redundancy imposes. This procedure is applied to data for England and Wales on bladder cancer mortality from 1951 to 1970.

Diffuse large B-cell lymphoma (DLBCL) patients with high Ki-67 expression receive limited benefits from R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) therapy. This study aims to compare the R-EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) and R-CHOP regimens as first-line therapy in DLBCL patients with high Ki-67 expression. Data f...