Among the drug delivery and targeting (DDT) routes, lung alveolar epithelium has been given enormous attentions in terms of the delivery of a wide range of macromolecules such as gene- or protein-based nanopharmaceuticals. However, little is known about cellular modulation of lung transport characteristics by endogenous and/or exogenous agents. Thus, in the current study, impact of dexamethason...

introduction: the aim of this study was to investigate the growth and development of mouse two cell embryo on human uterine polarized monolayers. material and methodes: human endometrial tissue was obtained from patients who had undergone total hysterectomy. then, epithelial cells were isolated by collagenase i 0.25% and cultured on either ecm gel coated millipore filter insert (polarized) or p...

Among the drug delivery and targeting (DDT) routes, lung alveolar epithelium has been given enormous attentions in terms of the delivery of a wide range of macromolecules such as gene- or protein-based nanopharmaceuticals. However, little is known about cellular modulation of lung transport characteristics by endogenous and/or exogenous agents. Thus, in the current study, impact of dexamethason...

Objective(s): Cisplatin is an effective antineoplastic agent; its clinical utility, however, is limited by a few salient toxic side effects like nephrotoxicity. This study aimed to determine the potential protective effects of tangeretin, a citrus-derived flavonoid, against renal tubular cell injury in cisplatin-induced renal toxicity of rats.Materials and Methods: Tangeretin was injected intra...

morphological and histochemical study of the abomasal epithelium in camel (camelus dromedarius) wascarried out by light and scanning electron microscopes. the lining of the abomasum was divided into fourregions, i.e. cardiac, pseudocardiac, fundic and pyloric. our investigation revealed that the cardiac andpseudocardiac regions occupy a wide part of the abomasum in camel and it reaches approxim...

Epithelial tissue is a type that mainly covers the surfaces of body and organs. Most epithelial tissues are composed highly proliferative cells, necessitating robust stem cell activity. also most common site cancers. Therefore, identifying cells their self-renewal mechanisms prerequisite for promoting homeostasis, understanding cancer pathogenesis, developing regenerative therapy prevention. Ov...

understanding the molecular mechanisms in regeneration could help the stem cell therapists to improve the clinical practices and could be considered a major milestone in the translation of stem cell research to clinics. chemokines have been described as one of the most significant singling networks in stem cells homing and regeneration of damaged organs. cxcr4/cxcl12 has been known as a key pla...

Animal studies showed that male gastric tissues respond more rapidly to Helicobacter pylori (H.pylori) infection but the possible mechanisms remained unclear. There is no data about gender specific activity of Androgen receptor (AR) as an independent unfavorable prognostic factor in gastric cancer and its interactions with H.pylori and angiogenesis in both genders. To compare the pathogenesis o...