Susanne Schoch*, Tobias Mittelstaedt, Pascal S Kaeser, Daniel Padgett, Nicole Feldmann, Vivien Chevaleyre, Pablo E Castillo, Robert E Hammer, Weiping Han, Frank Schmitz, Weichun Lin and Thomas C Südhof Emmy Noether Research Group, Institute of Neuropathology, Department of Epileptology, University Bonn, Bonn, Germany, Center for Basic Neuroscience, University of Texas Southwestern Medical Cente...

It is widely accepted that epilepsies are complex syndromes due to their multi-factorial origins and manifestations. Different mathematical and computational descriptions use appropriate methods to address nonlinear relationships, chaotic behaviors and emergent properties. These theoretical approaches can be divided into two major categories: descriptive, such as flowcharts, graphs and other st...

Despite the complexity and methodological difficulties in defining the concept of consciousness, it is a central concept in epileptology, and should thus be tractable for scientific analysis. In the present article, a two-dimensional model consisting of concepts related to the level and the contents of consciousness will be presented. This model has been found to be well suited for the descript...

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Several recent studies emphasize the high value of nonlinear EEG analysis particularly for improved characterization of epileptic brain states. In this review the authors report their work to increase insight into the spatial and temporal dynamics of the epileptogenic process. Specifically, they discuss possibilities for seizure anticipation, which is one of the most challenging aspects of epil...

Background. Mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS) constitutes a distinct clinical syndrome with variable pathogenesis. Extrahippocampal regions may be affected in MTLE/HS, association with cortical dysplasia is common and temporal polar cortex is frequently involved in seizure onset. Patients with dual pathology may have favourable outcome from the surgery provide...

Myoclonus refers to sudden, brief, shock-like involuntary movements, caused by muscular contractions (positive myoclonus) or inhibitions (negative myoclonus) arising from the central nervous system. This definition excludes the muscular twitches or fasciculation due to lesions of the lower motor neurons. 1 Myoclonus has been observed in patients with various neurological conditions including ep...