Epilepsy is among the most common serious neurological disorders and affects around 50 million people worldwide, 80% of which live in developing countries. Despite introduction several new Anti-Epileptic Drugs (AEDs) last two decades, one third treated patients have seizures refractory to pharmacotherapy. This highlights need develop treatments with drugs targeting alternative seizure-induction...

OBJECTIVES We investigated long-term (to 25 years) seizure prognosis and survival in people with newly diagnosed epilepsy in the community. We explored whether prognosis is different in those with epilepsy (>2 unprovoked seizures) and those with a single seizure at presentation. METHODS This is a prospective observational cohort study of people with newly diagnosed seizures. We investigated s...

introduction: this study was aimed to asses the rate of recurrence after the first unprovoked seizure in children. methods and materials: in a prospective study, we recruited 145 children who presented with primary unprovoked seizure and were followed for at least 12 months after the first seizure. results: seventy five children (51.7%) experienced subsequent seizures. the cumulative risk of se...

background: seizure is the most common pediatric neurologic disorder. epidemiological studies of childhood epilepsy are of importance to compare incidence and prevalence rates, age distribution, inheritance, seizure types, epilepsy syn­dromes and treatment strategies. since there is little information about prevalence of childhood seizure in iran, this study was aimed to determine the life time...

BACKGROUND AND PURPOSE To investigate the duration of seizures and its relationship to seizure type, epilepsy syndrome, and seizure clustering. METHODS We examined 1,251 seizures from 152 patients who underwent video-electrocorticographic monitoring with subdural electrodes. Their seizure duration, seizure types, epilepsy syndromes, and seizure clusters were analyzed. RESULTS The median sei...

Epilepsy is a debilitating condition affecting 1% of the population worldwide. Medications fail to control seizures in at least 30% of patients, and deep brain stimulation (DBS) is a promising alternative treatment. A modified clinical DBS hardware platform was recently described (PC+S) allowing long-term recording of electrical brain activity such that effects of DBS on neural networks can be ...

OBJECTIVE To examine the seizure trajectories of adults with epilepsy developing drug-resistant epilepsy (DRE) and to identify the predictors of seizure trajectory outcome. METHODS Adult patients failing two antiepileptic drugs (AEDs) due to inefficacy and starting their third AED at a tertiary epilepsy center were followed for seizure trajectory outcome during medical management. Seizure tra...

Electroencephalography (EEG) has an important role in the diagnosis and classification of epilepsy. It can provide information for predicting the response to antiseizure drugs and to identify the surgically remediable epilepsies. In temporal lobe epilepsy (TLE) seizures could originate in the medial or lateral neocortical temporal region, and many of these patients are refractory to medical tre...

Epilepsy patients experience challenges in daily life due to precautions they have to take in order to cope with this condition. When a seizure occurs, it might cause injuries or endanger the life of the patients or others, especially when they are using heavy machinery, e.g., deriving cars. Studies of epilepsy often rely on electroencephalogram (EEG) signals in order to analyze the behavior of...