UNLABELLED Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma. Current antiviral therapy fails to clear infection in a substantial proportion of cases. Drug development is focused on nonstructural proteins required for RNA replication. Individuals undergoing orthotopic liver transplantation face rapid, universal reinfection of the graft. Therefore, antivira...

Epigallocatechin gallate (EGCG), one of the major catechins found in green tea, was suggested to play a role as a chemopreventive agent in various human cancer models. In this study, we reported that EGCG has a profound antitumor effect on human tongue carcinoma cells by directly regulating glycolysis. EGCG dose-dependently inhibited anchorage-independent growth and short-term EGCG exposure sub...

The phenolic profile and antioxidant activities of oolong tea extract were investigated after tea was steeped in 90 or 100 C water for 3 or 10 min. The extraction yield increased with increasing temperature and extended steeping time. However, higher temperature and longer time (100 C water for 10 min) led to loss of phenolics. The aqueous extract of oolong tea (AEOT) at 100 C for 3 min exhibit...

The effects of pH (2.2–8.0) and temperature (25–100 °C) on the instrumental color a model beverage containing (−)-epigallocatechin-3-gallate (EGCG) were investigated. As increased, lightness (L*) decreased while redness yellowness (a* b*, respectively) increased. Using spectral scanning, it was possible to verify that changes might be related structural rearrangement EGCG aqueous solution in sy...

STUDY QUESTION Is epigallocatechin-3-gallate (EGCG) treatment effective in the treatment of fibrosis in endometriosis? SUMMARY ANSWER EGCG appears to have antifibrotic properties in endometriosis. WHAT IS KNOWN ALREADY Histologically, endometriosis is characterized by dense fibrous tissue surrounding the endometrial glands and stroma. However, only a few studies to date have evaluated candi...

Polyphenol E, available as Polyphenon E, is a green tea extract whose activity can be benchmarked to the presence of specific catechins such as epigallocatechin 3-gallate (EGCG). Herein, Polyphenon E is shown to reverse myeloid-derived suppressor cell activity, linking the activity of a natural product extract to cell-mediated immunity.

Green tea catechins, including (-)-epicatechin (EC), (-)-epicatechin gallate (ECG), (-)-epigallocatechin (EGC) and (-)-epigallocatechin gallate (EGCG), are oxidized and dimerized during the manufacture of black tea and oolong tea to form orange-red pigments, theaflavins (TF), a mixture of theaflavin (TF1), theaflavin-3-gallate (TF2A), theaflavin-3'-gallate (TF2B) and theaflavin-3,3'-digallate (...

The preventive effects of C-2 epimeric isomers of (-)-epigallocatechin-3-O-gallate (EGCG) and the O-methylated derivative, (-)-epigallocatechin-3-O-(3-O-methyl)gallate (EGCG3''Me), against ovalbumin-induced type I allergy in male mice were investigated. EGCG and EGCG3''Me exhibited strong antiallergic effects by oral administration at doses of 25 and 50 mg/kg body weight. The antiallergic effec...

A simple, rapid and reliable method of high performance liquid chromatography (HPLC) was developed for the simultaneous determination of bioactive compounds in oolong teas. The optimized method consisted of the use of a C18 reversed-phase column, an isocratic elution system (2 ml/min) of water:acetonitrile (87:13) containing 0.05% trifluoroacetic acid and the detection wavelength of 210 nm. The...