(-)-Epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECg), and (-)-epigallocatechin gallate (EGCg) were prepared from crude catechins (containing 90% cateehin in total) as described in our previous paper,i) Crude theaflavins, theafiavin (TFI), theaflavin monogallate A (TF2A), theafiavin monogallate B (TF2B), and theaflavin digallate (TF3) were prepared from black tea by ou...

Fuzhuan brick tea, a kind of dark tea consumed mainly in the border regions of Southwestern and Northwestern China since the 1860s, is produced from the leaves of Camellia sinensis var. sinensis by microbial fermentation. From this special fermented tea, a new norisoprenoid, 3R,9R-oxido-5-megastigmene, was isolated, together with α-linolenic acid, strictin, isovitexin, astragalin, (+)-catechin,...

Tea is the most widely consumed beverage in the world. Tea leaves are a source of polyphenols, especially catechins, a decisive group for their antioxidative activity. This paper reviews what is known of green tea species, its leaves processing and changes occurring in tea components. The main green tea polyphenols are catechins: (±)-catechin C, (-)-epicatechin EC, (+)-gallocatechin GC, (-)-epi...

In the present study, we found that three enzymes, MVK, MDD and FPPS, in the mevalonate pathway (MVP) of cholesterol biosynthesis, can be simultaneously inhibited by two green tea polyphenols ((-)-epicatechin-3-gallate, ECG; (-)-epigallocatechin-3-gallate, EGCG). Molecular dynamics simulations and pharmacophore studies were carried out to elucidate the tri-targeted inhibition mechanisms. Our re...