Background Application of topical moisturizers is an essential part of the management of atopic dermatitis (AD). Linoleic acid (LA), the most abundant fatty acid in the epidermis, and its derivatives have an essential role in the structure and function of the epidermal barrier, and their defects are prominent in AD. The aim of this study was to compare the efficacy and safety of two cosmetic pr...

background: the present study was undertaken to investigate the correlation of epidermal growth factor receptor (egfr) expression with grade of transitional cell carcinoma (tcc). methods: tumor samples of 75 patients from mostafa khomaini hospital with transitional cell carcinoma of the bladder were analyzed by immunohistochemistry for expression of egfr. in this context, we assigned the bladde...

Protein phosphatase 2A (PP2A) is a critical target to control cumulative oxidative stress and chronic inflammation during skin aging by reversible methylation of the C-terminal leucine PP2A catalytic subunit (PP2Ac). A novel, proprietary Activated-Grape Seed Extract (AGSE), enriched for PP2A-activating flavonoids, was recently developed, has demonstrated potent antioxidant anti-inflammatory act...

In this study, the effect of variety of Nano- additives doping on the hydration resistance of the MgO-CaO system was investigated. Samples were prepared from calcined dolomite and magnesite. Nano-additives that contained cations with various valences (trivalent and tetravalent) used as  a dopant. The bulk density, apparent porosity and hydration resitance were studied and evaluated. Also, phase...

AbstractEpidermal inclusion cysts are uncommon in the breast, but the consequences can besevere when these cysts occur in the breast parenchyma. Here, we report two suchcases. The patient in case 1 was an 37-year-old woman with a 3-cm palpable mass inthe right breast. Mammography revealed a round and smoothly outlined mass, whichindicated a benign tumor, and sonography showed an irregularly sha...

In this study the effect of nano meter size ZrO2 particles on the microstructure, densification and hydration resistance of magnesite –dolomite refractories was investigated. 0, 2, 4, 6 and 8 wt. % ZrO2 particles that were added to magnesite –dolomite refractories containing 35 wt. % CaO. The Hydration resistance was measured by change in the weight of specimens after 72 h at 25℃ an...

HYALURONIC ACID: HOW SUCH A SIMPLE MOLECULE GOT SO COMPLICATED Hyaluronic acid (HA), probably the most recognized ingredient in the skincare industry, has undergone a remarkable scientific evolution since it was first isolated in 1934.1 Despite its widespread use as a topical skincare ingredient and injectable dermal filler, relatively little is known about the cellular pathways that control HA...

Restoration of an epidermal barrier is a definitive requirement for wound closure. To determine formation of an epidermal barrier as a function of hydration of the stratum corneum, we measured surface electrical capacitance (SEC) of the epidermis in cultured skin substitutes (CSS) in vitro and after grafting to athymic mice. CSS were prepared from human keratinocytes and fibroblasts attached to...