نتایج جستجو برای: epidermal growth factor receptor

تعداد نتایج: 1911087  

Journal: :Chemical biology & drug design 2011
Shaopeng Chen Xiaowei Zhang Junlei Wang Shengbiao Wan Meiyu Geng Tao Jiang

A new series of potential epidermal growth factor receptor inhibitors possessing bisquinazoline and saccharide moieties were designed and synthesized. The biological results demonstrated that the synthetic derivatives significantly inhibited epidermal growth factor receptor enzymatic activity in vitro. Of them, compound 14b showed the highest inhibitory rate toward epidermal growth factor recep...

Journal: :Molecular cancer therapeutics 2009
Juliana Bentes Hughes Christian Berger Marianne Skeie Rødland Max Hasmann Espen Stang Inger Helene Madshus

Epidermal growth factor receptor (EGFR) and ErbB2 readily form heterodimers when both are expressed in the same cell and the EGFR is activated by one of its ligands. Our data show that such heterodimers are constitutively formed also in a ligand-independent manner on overexpression of EGFR and ErbB2 in porcine aortic endothelial cells. Interestingly, cross-linking experiments showed that incuba...

Amin Aidun Arianeb Mehrabi Fatemeh Elham Kani Mehdi Chavoshi-Nejad Seyed Abbas Mirmalek Seyed Alireza Salimi-Tabatabaee Soheila Yadollah-Damavandi Tina Parsa Yekta Parsa,

Introduction: Overexpression of Human Epidermal Growth factor Receptor-2 (HER-2) is one of the most important prognostic and predictive factors of breast cancer, observed in 25% - 30% of breast carcinoma patients leading to poor prognosis and feasible anti HER-2 antibody drugs. The objective of this study was to evaluate the HER-2 frequency in target population and its correlat...

Journal: :Cancer research 1990
M von Knebel Doeberitz L Gissmann H zur Hausen

Squamous cell carcinomas of the human anogenital tract are usually associated with infection of specific types of human papillomaviruses (HPV 16, 18, 31, 33, 35). The intracellular concentration of human papillomavirus early gene products E6 and E7 has been directly linked to the proliferative capacity of cervical cancer cells. Since the expression rate of epidermal growth factor receptor corre...

Journal: :Cancer research 2005
Antonio Jimeno Belen Rubio-Viqueira Maria L Amador Darin Oppenheimer Nadia Bouraoud Peter Kulesza Valeria Sebastiani Anirban Maitra Manuel Hidalgo

Analysis of gene expression of cancer cell lines exposed to erlotinib, a small molecule inhibitor of the epidermal growth factor receptor (EGFR), showed a marked increase in EGFR mRNA in resistant cell lines but not in susceptible ones. Because cetuximab induces EGFR down-regulation, we explored the hypothesis that treatment with cetuximab would interfere with erlotinib-induced EGFR up-regulati...

Journal: :archives of breast cancer 0
safa najafi breast diseases department, breast cancer research center, acecr, tehran, iran reza mehdizadeh department of cell and molecular biology, college of biology, university of tehran, tehran, iran eissa jahanzad department of pathology, tehran university of medical sciences, tehran, iran asiie olfatbakhsh breast diseases department, breast cancer research center, acecr, tehran, iran arash jenabian islamic azad university of tehran, medical branch, tehran, iran gholamreza esmaeeli-javid biostatistics and epidemiology committee, iranian center for medical lasers (icml), acecr, tehran, iran

background: triple-negative breast cancer (tnbc) carries a poor prognosis and therapeutic options are limited to date. the aim of this study was to investigate to what extent the epidermal growth factor receptor (egfr), vascular endothelial growth factor receptor 2 (vegfr2), hypoxia inducible factor-1 alpha (hif-1α) and insulin-like growth factor-1 receptor (igf-1r) are expressed in tnbc and to...

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