Blood clots are made up of platelets and fibrin gel, and the relative amount of fibrin is strongly influenced by the shear rate. In order to explore this phenomenon, this paper presents a model of fibrin gel formation over the surface of an injured blood vessel in a shear flow. A condition for gelation including source and sink terms of polymer is derived. A simplified model of coagulation, inv...

The EcoCyc database characterizes the known network of Escherichia coli small-molecule metabolism. Here we present a computational analysis of the global properties of that network, which consists of 744 reactions that are catalyzed by 607 enzymes. The reactions are organized into 131 pathways. Of the metabolic enzymes, 100 are multifunctional, and 68 of the reactions are catalyzed by >1 enzyme...

In the present paper, we report on enzyme-initiated self-assembly of Fmoc (fluoren-9-ylmethoxycarbonyl)-tyrosine hydrogels by enzymatic dephosphorylation under physiological conditions and provide evidence for the ability to control the modulus. Upon enzyme action, a self-assembling network of interconnecting fibres is formed, observed by cryo-SEM (scanning electron microscopy) and TEM (transmi...

A two-site spatial coagulation model is considered. Particles of masses m and n at the same site form a new particle of mass m + n at rate mn . Independently, particles jump to the other site at a constant rate. The limit (for increasing particle numbers) of this model is expected to be non-deterministic after the gelation time, namely, one or two giant particles randomly jump between the two s...

In this issue of Chem, Hess et al. describe a droplet-based microfluidic platform for the acquisition transient kinetic data enzyme-catalyzed reactions. Compared with conventional equipment, their reduces assay volumes by up to six orders magnitude and allows 9,000 reactions be screened per minute.