The present work is part of a wide research project aimed to elucidate the mechanism of the metabolic activation of the antitumor imidazoacridinone agent C-1311 selected for clinical trials. The objectives of the investigations presented here were: (i) to examine the enzymatic transformation of the reference compound 2-hydroxyacridinone and (ii) to test the similarity between enzymatic and elec...

A new potentially promising visible-light driven photobioreactor synthesizes fine chemical via photobiocatalysis by generating NADH in a non-enzymatic light-driven process and coupling it to the enzymatic dark reaction catalysis.

The polymerization of vinyl monomers with cleavable enzymatic substrates has been shown to lead to water-soluble double-hydrophilic block copolymers which, upon enzymatic activation of the diblock copolymers, become amphiphilic and undergo self-assembly into colloidal nanostructures. The ability to change the chemical and physical characteristics of polymeric materials by an enzymatic reaction ...

New crystallographic techniques make it possible to observe directly all of the intermediates in an enzymatic reaction. Such a series of structures can be combined to create a detailed movie of enzymatic catalysis.