OBJECTIVES An unexpectedly high proportion of children were admitted for severe respiratory infections at the Oslo University Hospital, Ullevål, Norway, during September and October, 2014. In light of the ongoing outbreak of enterovirus-D68 (EV-D68) in North America a real-time RT-PCR for screening of enterovirus and enterovirus D68 was established. DESIGN We developed a duplex real-time RT-P...

Campylobacter enteritis, giardiasis, legionnaires' disease, primary amoebic meningoencephalitis, and the viral haemorrhagic fevers are among the "new" diseases. In hospitals group B streptococcal infections have been recognised, there have been episodes of hospital-acquired enterovirus infections, and developments in surgical prostheses and immunosuppression have been followed by the appearance...

Enteroviruses have been reported in encephalitis cases. However, clinical and epidemiological characteristics of enteroviruses in encephalitis are not fully established. We prospectively investigated 204 children with encephalitis over a period of 2 years (2009 to 2010) for enterovirus. Enterovirus was detected in 45 specimens (22.1%); of these, 40 were typed by seminested reverse transcription...

A Chinese human enterovirus 85 (HEV85) isolate, HTYT-ARL-AFP02F/XJ/CHN/2011, was isolated from a stool specimen of a child with acute flaccid paralysis in Xinjiang, China, in 2011. The complete genome sequence revealed that a natural intertypic recombination event had occurred between HEV85 and a previously undescribed serotype of HEV-B.

The first upsurge of enterovirus D68 (EV-D68), a causative agent of acute respiratory infections (ARIs), in Japan was reported in Osaka City in 2010. In this study, which began in 2010, we surveyed EV-D68 in children with ARIs and analyzed sequences of EV-D68 strains detected. Real-time PCR of 19 respiratory viruses or subtypes of viruses, including enterovirus, was performed on 2,215 specimens...

We describe a patient with enterovirus encephalitis who presented with oral ulcers and a rash (Figs 1-3). Although the rash appeared to be non-specific, enterovirus was immediately suspected as the aetiological agent based on its hand, foot, and mouth (HFM), and body distribution. Enterovirus type 71 (EV71) was promptly identified by reverse transcription–polymerase chain reaction at multiple s...

OBJECTIVE Polymorphisms in the IFIH1 (common rs1990760 and four rare rs35667974, rs35337543, rs35744605, rs35732034) have been convincingly associated with type 1 diabetes. The encoded protein (interferon-induced helicase C domain-containing protein 1) senses double-stranded RNA during replication of Picornavirales, including Enterovirus, a genus suspected in the etiology of type 1 diabetes. We...

INTRODUCTION Fever in newborn infants may be due to an invasive infection with potential morbidity and mortality. Our aim was to describe the characteristics and outcome of group of febrile neonates with severe enterovirus infection compared to a group of neonates with severe bacterial infection. PATIENTS AND METHODS Prospective study including all neonates (<29 days old) admitted to a teachi...

background: human enteroviruses (evs) may have a role as a possible risk factor in the pathogenesis of mi. the aim of this study was to evaluate the presence of enterovirus genomic rna in peripheral blood samples of patients with acute myocardial infarction (mi). methods: we investigated the presence of enterovirus genomic rna in the peripheral blood of 115 patients with acute mi hospitalized i...

OBJECTIVE To determine whether enterovirus RNA can be demonstrated in archival necropsy material in acute myocarditis. DESIGN Analysis of paraffin embedded myocardial tissue from cases of acute myocarditis. SETTING University virology department. METHODS Extraction of RNA from tissue followed by polymerase chain reaction (PCR) and DNA sequence analysis. PATIENTS Six patients with histol...