Antimicrobial agent residues are becoming an intractable environmental problem in soil, surface, and underground water. To obtain a broad profile of residues in animal wastewater and surface water, 24 animal wastewater, 8 animal farm effluent, 18 river water, and 8 pond water samples taken in Jiangsu in eastern China were monitored for enrofloxacin, ciprofloxacin, and florfenicol using solid ph...

The aim of the study was to investigate the influence of administration of chlorpyrifos and/or enrofloxacin on the activity of chosen antioxidative enzymes i.e.: superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in erythrocytes of rats. Chlorpyrifos was administered by stomach tube during 28 days at a dose of 3 mg/kg bw (0.02 LD50), and enrofloxacin was administered by...

Four groups of six Holstein calves were inoculated with 3.6 × 10(7) erythrocytes parasitized with Anaplasma marginale. The criteria for treatment of calves were increasing A. marginale rickettsemia and 30% reduction of baseline packed cell volume (PCV) of each animal. Group 1 (G1) received 7.5 mg.kg(-1) of enrofloxacin in a single dose; Group 2 (G2) 7.5 mg.kg(-1) of enrofloxacin twice every thr...

The purpose of this study was to determine the presence fluoroquinolones (enrofloxacin and ciprofloxacin) residues in fresh chicken meat evaluate its consumption risk adult population Indonesia. A total 55 chicken-meat samples were collected from Districts Malang Blitar, East Java Province, Indonesia, April 2017. Detections enrofloxacin ciprofloxacin carried out using high-performance liquid ch...

Aim: A pharmacological study was undertaken to evaluate the safety and adverse effects of enrofloxacin administration in broiler chickens by assessing the serum biochemical parameters, associated histopathological and ultra structural changes in liver and kidney. Materials and Methods: Birds in the treatment group were administered with enrofloxacin at the recommended therapeutic dose 10mg/kg b...

per cent compared with 57.1 per cent, respectively). Bacteriological cure rates were significantly higher in the enrofloxacin group on day 2 (odds ratio for cure was 3.32, P=0.002). Bacteriological cure rates on day 21 were similar in both treatment groups (90.5 per cent in the enrofloxacin group and 86.8 per cent in the non-treated group). Survival rates of cows at day 21 or survival in the he...

One major determinant of the efficacy of antibiotics on gram-negative bacteria is the passage through the outer membrane. During transport of the fluoroquinolone enrofloxacin through the trimeric outer membrane protein OmpF of Escherichia coli, the antibiotic interacts with two binding sites within the pore, thus partially blocking the ionic current. The modulation of one affinity site by Mg(2+...

The minimum inhibitory concentration (MIC) of an antimicrobial drug for a bacterial pathogen is used as a measure of the bacterial susceptibility to the drug. However, relationships between the antimicrobial concentration, bacterial susceptibility, and the pharmacodynamic (PD) inhibitory effect on the bacterial population are more complex. The relationships can be captured by multi-parameter mo...

BACKGROUND Antibiotic resistance has become a serious global problem and is steadily increasing worldwide in almost every bacterial species treated with antibiotics. In aquaculture, the therapeutic options for the treatment of A. hydrophila infection were only limited to several antibiotics, which contributed for the fast-speed emergence of drug tolerance. Accordingly, the aim of this study was...

In this publication we present a comparative study of effectiveness enrofloxacin and moxifloxacin for treatment chickens, experimentally infected with Salmonella infantis . The chickens received both drugs in water-soluble form via drinking water ad libitum at concentrations 200 mg/L, 100 50 mg/L 25 one day before the challenge then four consecutive days. were challenged by intraperitoneal inje...