Previous studies have examined the role of three NOS3 gene polymorphisms [G894T, T-786C, and the variable number of tandem repeats 4b/a (VNTR 4b/a)] in the susceptibility to preeclampsia with inconclusive findings. We therefore conducted an updated meta-analysis by including more studies. The most appropriate genetic model was chosen for each polymorphism by using a well-established method. Poo...

Atrial fibrillation (AF) commonly occurs in the context of structural heart disease and is accompanied by atrial remodelling. The latter refers to any change in atrial function that promotes AF or occurs as a consequence of the arrhythmia. Atrial remodelling in the aged heart and during heart failure is characterized by pronounced fibrosis leading to heterogeneous slowing conduction of and prol...

Cardiovascular benefits from estradiol activation of nitric oxide endothelial production may depend on vascular wall and on estrogen receptor alpha (ESR1) and nitric oxide synthase (NOS3) polymorphisms. We have evaluated the microcirculation in vivo through nailfold videocapillaroscopy, before and after acute nasal estradiol administration at baseline and after increased sheer stress (postocclu...

Studies investigated the association between endothelial NO synthase gene polymorphisms and hypertension-reported contradicted or nonconclusive results. A meta-analysis of 35 genetic association studies that examined the relation between hypertension and the G894T, 4a/b, T786C, and G23T polymorphisms of the endothelial nitric oxide synthase gene was carried out. Subgroup analysis by ethnicity a...

background: reduced bioavailability of nitric oxide (no) and the t?786c polymorphism of endothelial nitric oxide synthase (enos) gene have been reported as risk factors for the development of coronary artery disease (cad) with conflicting results. we investigated the association of plasma no levels, t?786c genetic polymorphism, and gene expression levels of enos with cad risk in an iranian subp...

110 Ann Dermatol Received May 12, 2014, Revised September 9, 2014, Accepted for publication September 11, 2014 Corresponding author: Min Zhang, Department of Dermatology, WestChina Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China. Tel: 86-28-85423315, Fax: 8628-85422114, E-mail: [email protected] This is an Open Access article distributed under the terms of the Creati...