A simple explanation for the symmetry of the genetic code has been suggested. An alternative to the wobble hypothesis has been proposed. The facts revealed in this study offer a new insight into physical mechanisms of the functioning of the genetic code. The wobble hypothesis, which was first proposed more than 40 years ago [1], can explain two events: 1) formation of the uracil­guanine pair as...

Non-classical protomerism of Schiff bases offers several advantages; for example, specific interactions in the -C[double bond, length as m-dash]N- linkage can be controlled and differentiated because the interactions are not governed by keto-enol tautomerism. Herein, the pH sensing properties of a new protomeric Schiff base probe () are reported. In particular, among several acids, the probe di...

In previous publications we reported abundant empirical evidence of the spontaneous oscillatory transenantiomerization of optically pure enantiomeric 2-arylpropionic acids (2-APAs), resulting in a racemic mixture of the pairs of enantiomers. Our experiments were performed with 2phenylpropionic acid, ibuprofen, and naproxen. The last two compounds are non-steroidal anti-inflammatory drugs (NSAID...

It has recently been reported that aluminum plays a very important role in reducing the activity of Krebs-cycle enzymes and glutamate dehydrogenase in rat brain homogenate. Therefore, it is necessary to identify the aluminum binding ability with the pivotal substrate alpha-ketoglutarate in biological systems. The interactions of aluminum with alpha-ketoglutarate were studied with pH-potentiomet...

The usefulness of thin-layer chromatography (TLC) as an efficient measuring technique in the studies of oscillatory trans-enantiomerization of profens from the S to the R configuration (and vice versa) during their storage as 70% ethanol solutions is demonstrated in the literature. S-(+)-ibuprofen, S-(+)-naproxen, and S,R-(+/-)-2-phenylpropionic acid are utilized as the test profens. It is prov...

A compound exhibits (prototropic) tautomerism if it can be represented by two or more structures that are related by a formal intramolecular movement of a hydrogen atom from one heavy atom position to another. When the movement of the proton is accompanied by the opening or closing of a ring it is called ring-chain tautomerism. This type of tautomerism is well observed in carbohydrates, but it ...

Complexes of Ni(II) (1), Cu(II) (2) and Cd(II) (3) with a novel Schiff base N-(2-2-[1-(3aminophenyl) ethylidene] hydrazino-2-oxoethyl) benzamide (LH) have been prepared and characterized by elemental analysis, TG-DTA, magnetic, electronic, molar conductivity measurements, IR, SEM, NMR, ESR and mass studies. It is observed that all the complexes having 1:1 metal-ligand stoichiometry are tetracoo...